Age-related grey matter changes in preterm infants: an MRI study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tzarouchi, L. C.
Astrakas, L. G.
Xydis, V.
Zikou, A.
Kosta, P.
Drougia, A.
Andronikou, S.
Argyropoulou, M. I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Neuroimage
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Grey matter (GM) maturation has not been previously studied in healthy preterm children. The purpose of this study was to evaluate the age dependency of GM development in 116 GM areas in preterm subjects. Sixty one preterm infants (corrected age: 13.7+/-9.92 months, gestational age: 33.4+/-1.9 weeks) with normal structural appearance on MRI were included in the study. Using a T1-weighted high resolution 3D spoiled gradient echo sequence, volumes of 116 GM areas were calculated after their segmentation using the Voxel Based Morphometry Toolboxes and the Individual Brain Atlas Statistical Parametric Mapping (IBASPM) software packages. Non linear regression analysis assessed age dependency of volume data for every GM area using the monoexponential function y=A-Bexp(-x/C). All supratentorial GM areas followed the monoexponential function model reasonably well. Cerebellar structures had a poor goodness of fit. Volume increase of the individual GM areas followed an inferior to superior and a posterior to anterior pattern. The putamen, thalamus, and caudate nucleus reached 99% of the final volume earlier than most cortical GM areas. The visual cortex and the postcentral and precentral cortices matured earlier than the parietal, frontal and temporal cortices. The fronto-occipital asymmetry or torque seen in adults was observed in the preterm infants; the left occipital areas reached maturation earlier than the right, while the right prefrontal and frontal areas matured earlier than the left. To conclude, GM development progresses in a region-specific manner coinciding with functional, phylogenetical and regional white matter (WM) maturation.
Περιγραφή
Λέξεις-κλειδιά
Aging/*pathology, Brain/*cytology, Female, Humans, Imaging, Three-Dimensional/*methods, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging/*methods, Male, Neurons/*cytology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19348950
http://ac.els-cdn.com/S1053811909003334/1-s2.0-S1053811909003334-main.pdf?_tid=95ea89198961445c4400771d8678f017&acdnat=1333020240_68ff3ea2ca85a24d8158acd70fe2bba8
http://ac.els-cdn.com/S1053811909003334/1-s2.0-S1053811909003334-main.pdf?_tid=95ea89198961445c4400771d8678f017&acdnat=1333020240_68ff3ea2ca85a24d8158acd70fe2bba8
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής