Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells
Φόρτωση...
Ημερομηνία
Συγγραφείς
Goulas, V.
Exarchou, V.
Troganis, A. N.
Psomiadou, E.
Fotsis, T.
Briasoulis, E.
Gerothanassis, I. P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Wiley-VCH Verlag
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Mol Nutr Food Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Olive oil compounds is a dynamic research area because Mediterranean diet has been shown to protect against cardiovascular disease and cancer. Olive leaves, an easily available natural material of low cost, share possibly a similar wealth of health benefiting bioactive phytochemicals. In this work, we investigated the antioxidant potency and antiproliferative activity against cancer and endothelial cells of water and methanol olive leaves extracts and analyzed their content in phytochemicals using LC-MS and LC-UV-SPE-NMR hyphenated techniques. Olive-leaf crude extracts were found to inhibit cell proliferation of human breast adenocarcinoma (MCF-7), human urinary bladder carcinoma (T-24) and bovine brain capillary endothelial (BBCE). The dominant compound of the extracts was oleuropcin; phenols and flavonoids were also identified. These phytochemicals demonstrated strong antioxidant potency and inhibited cancer and endothelial cell proliferation at low micromolar concentrations, which is significant considering their high abundance in fruits and vegetables. The antiproliferative activity of crude extracts and phytochemicals against the cell lines used in this study is demonstrated for the first time.
Περιγραφή
Λέξεις-κλειδιά
angiogenesis, cancer, lc-spe-nmr, oleuropein, olive leaf extract, olea-europaea l., performance liquid-chromatography, integrase inhibitors oleuropein, low-density-lipoprotein, molecule hiv-1 fusion, phenolic-compounds, mediterranean diet, antioxidant activity, natural-products, oil
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000266308600010
http://onlinelibrary.wiley.com/store/10.1002/mnfr.200800204/asset/600_ftp.pdf?v=1&t=h0dvekd5&s=9807c03159b3de3b80887e9ef615a65b43480b51
http://onlinelibrary.wiley.com/store/10.1002/mnfr.200800204/asset/600_ftp.pdf?v=1&t=h0dvekd5&s=9807c03159b3de3b80887e9ef615a65b43480b51
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας