Enantioselective binding of Lambda- and Delta-[Ru(bpy)(2)(HPIP)]Cl-2 (HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline) to the hexanucleotide [d(5 '-GTCGAC-3 ')2]
| dc.contributor.author | Garoufis, A. | en |
| dc.contributor.author | Liu, J. G. | en |
| dc.contributor.author | Ji, L. N. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.date.accessioned | 2015-11-24T16:57:44Z | |
| dc.date.available | 2015-11-24T16:57:44Z | |
| dc.identifier.issn | 0162-0134 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10611 | |
| dc.rights | Default Licence | - |
| dc.subject | ru(ii) enantiomers | en |
| dc.subject | oligonucleotide | en |
| dc.subject | hpip | en |
| dc.subject | nmr | en |
| dc.subject | esi-ms | en |
| dc.subject | minor-groove binding | en |
| dc.subject | ionization mass-spectrometry | en |
| dc.subject | sequential resonance assignments | en |
| dc.subject | DNA-binding | en |
| dc.subject | ruthenium(ii) complexes | en |
| dc.subject | h-1-nmr spectra | en |
| dc.subject | nmr evidence | en |
| dc.subject | intercalation | en |
| dc.subject | d(gtcgac)(2) | en |
| dc.subject | spectroscopy | en |
| dc.title | Enantioselective binding of Lambda- and Delta-[Ru(bpy)(2)(HPIP)]Cl-2 (HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline) to the hexanucleotide [d(5 '-GTCGAC-3 ')2] | en |
| heal.abstract | Multidimensional NMR techniques (1D (HNMR)-H-1, 2D DQF (HH)-H-1-H-1 COSY and 2D (HH)-H-1-H-1 NOESY), electrospray ionization mass spectrometry (ESI-MS) and electronic spectroscopy, were performed to study the interactions of the enantiomers Lambda- and Delta-[Ru(bpy)(2)(HPIP)]Cl-2, (HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthro-line) with the self complementary hexanucleotide duplex d(5'-GTCGAC-3')(2). The results show that the Delta-[Ru(bpy)(2)(HPIP)]Cl-2 binds tightly to the oligonucleotide, by intercalation of the ligand HPIP, between the A5 and C6 base sequence of the same strand, probably through the minor groove. Lambda-enantiomer binds weakly, suggesting groove interactions with the hexanucleotide duplex. ESI-MS spectrometry and UV-vis spectroscopy also confirmed these observations. (C) 2002 Elsevier Science Inc. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000181146400014 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0162013402005755/1-s2.0-S0162013402005755-main.pdf?_tid=96c3b76b34a5a303bb1e7123014ace52&acdnat=1333029207_f1e125c74b354a8ce6b73be99c2fa560 | - |
| heal.journalName | J Inorg Biochem | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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