Gender effects on novel indexes of heterogeneity of repolarization in patients with stable coronary artery disease
Φόρτωση...
Ημερομηνία
Συγγραφείς
Korantzopoulos, P.
Letsas, K. P.
Christogiannis, Z.
Kalantzi, K.
Massis, I.
Goudevenos, J. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Hellenic J Cardiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
INTRODUCTION: There appear to be important gender differences with respect to the incidence and clinical course of arrhythmias. It has been shown that women with coronary artery disease (CAD) have a lower rate of ventricular arrhythmias and sudden cardiac death (SCD) than men. The T peak-to-end (Tpe) interval and the Tpe/QT ratio represent novel markers of arrhythmic risk that possibly correspond to the spatial dispersion of ventricular repolarization. We sought to examine the effect of gender on these indexes in patients with stable CAD. METHODS: We studied 119 patients (age 62 +/- 9 years, 85 men) with stable CAD. We recorded the demographic and clinical characteristics as well as electrocardiographic indexes of repolarization, such as corrected QT interval (QTc), Tpe interval, and Tpe/QT ratio. The QT interval was measured in each of the 12 leads while Tpe interval was measured in the precordial leads. RESULTS: There were no significant differences in the demographic and clinical characteristics between men and women. The QTc intervals were comparable between the 2 groups (389 [368-419] ms in men, 374 [348-421] ms in women; p=0.39). A significant difference was observed with respect to Tpe (80 [58-86] ms in men vs. 48 [39-65] ms in women, p=0.008) and Tpe/QT ratio (0.20 [0.17-0.23] in men vs. 0.14 [0.12-0.22] in women, p=0.034). CONCLUSIONS: Women with CAD have a lower Tpe interval and a lower Tpe/QT ratio compared to men. The decreased dispersion of ventricular repolarization may contribute to the lower incidence of ventricular arrhythmias and SCD in women with CAD.
Περιγραφή
Λέξεις-κλειδιά
Coronary Artery Disease/*physiopathology, *Electrocardiography, Female, Humans, Male, Middle Aged, Sex Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21933762
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής