An electron microscopic and biochemical study of the effects of cyclic 3', 5'-AMP, ergotamine or propranolol on the lysosomes of newborn rat hepatocytes
| dc.contributor.author | Kotoulas, A. O. | en |
| dc.contributor.author | Kotoulas, O. B. | en |
| dc.contributor.author | Kalamidas, S. | en |
| dc.date.accessioned | 2015-11-24T19:36:39Z | |
| dc.date.available | 2015-11-24T19:36:39Z | |
| dc.identifier.issn | 0213-3911 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23916 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Animals, Newborn | en |
| dc.subject | Autophagy | en |
| dc.subject | Cyclic AMP/antagonists & inhibitors/*pharmacology | en |
| dc.subject | Ergotamine/*pharmacology | en |
| dc.subject | Glycogen/metabolism | en |
| dc.subject | Liver/*drug effects/ultrastructure | en |
| dc.subject | Lysosomes/*drug effects/ultrastructure | en |
| dc.subject | Maltose/metabolism | en |
| dc.subject | Propranolol/*pharmacology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Strains | en |
| dc.subject | Vacuoles/drug effects/ultrastructure | en |
| dc.subject | alpha-Glucosidases/drug effects | en |
| dc.title | An electron microscopic and biochemical study of the effects of cyclic 3', 5'-AMP, ergotamine or propranolol on the lysosomes of newborn rat hepatocytes | en |
| heal.abstract | The effects of cyclic 3',5'-AMP, ergotamine or propranolol on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry. Cyclic AMP enhanced the normal postnatal rise in the glycogen-hydrolysing activity of acid alpha 1, 4 glucosidase but had no effect on the maltose-hydrolysing activity of the enzyme. The results suggest that these activities may be due to different enzymes. Propranolol prevented the postnatal increase in the glycogen-hydrolysing activity of acid glucosidase and the breakdown of lysosomal glycogen, indicating that these phenomena represent beta-adrenergic functions in newborn rats. Ergotamine also inhibited the postnatal increase in this activity and the lysosomal glycogen mobilization. A reasonable explanation for these results is that ergotamine interferes with the action or formation of cyclic AMP. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/1667279 | - |
| heal.journalName | Histol Histopathol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1991 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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