FSH, TSH, T3 and T4 changes in relation to plasma copper and zinc alterations during D-penicillamine administration in female Wistar rats

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dc.contributor.authorTsanadis, G.en
dc.contributor.authorSotiriadis, A.en
dc.contributor.authorVezyraki, P.en
dc.contributor.authorKalfakakou, V.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorDalkahtsis, N.en
dc.contributor.authorEvangelou, A.en
dc.contributor.authorStefos, T.en
dc.date.accessioned2015-11-24T19:15:15Z
dc.date.available2015-11-24T19:15:15Z
dc.identifier.issn0271-5317-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21484
dc.rightsDefault Licence-
dc.subjectwistar ratsen
dc.subjectcopperen
dc.subjectd-penicillamineen
dc.subjectzincen
dc.subjectfshen
dc.subjectt3en
dc.subjectt4en
dc.subjecttshen
dc.subjectthyroid-hormone metabolismen
dc.subjectseleniumen
dc.subjectdeficiencyen
dc.subjectpituitaryen
dc.subjectcomplexesen
dc.subjectserumen
dc.titleFSH, TSH, T3 and T4 changes in relation to plasma copper and zinc alterations during D-penicillamine administration in female Wistar ratsen
heal.abstractZinc and copper are considered to antagonize each other in several organs, while they play a significant role in the regulation and function of many systems. D-penicillamine was administered to 19 female Wistar rats for 68 days, 1 g/d/kg B.W. Plasma copper and zinc levels, as well as serum T3, T4, TSH and FSH were measured at days 50, 53, 54, 58, 62 and 68. Copper concentration presented a significant decrease. Zinc showed an initial increase by day 54, followed by a subsequent decrease. FSH levels decreased, presenting a pattern identical with that of copper. T3 and -especially- T4 alterations were similar to that of zinc and copper, whereas TSH alterations were inverse to them. it is concluded that copper and zinc alterations, induced by d-penicillamine administration, can significantly affect pituitary sex hormones (TSH) and hypothalamic-pituitary-thyroid axis in rats. (C) 2003 Elsevier Science Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000180640900013-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0271531702004803/1-s2.0-S0271531702004803-main.pdf?_tid=c0c13b1b65dd30e3658cde7b51ed382c&acdnat=1332741911_84f241a683a1d872779f4e29ec730770-
heal.journalNameNutrition Researchen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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