Is the E-cadherin downregulation observed in Helicobacter pylori infection associated with gastric cancer development? An additional element in the disease jigsaw

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dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorPapalimneou, V.en
dc.contributor.authorEvangelou, A.en
dc.contributor.authorKalfakakou, V.en
dc.contributor.authorKiortsis, D.en
dc.contributor.authorKolettas, E.en
dc.contributor.authorAlamanos, J.en
dc.contributor.authorCharalabopoulos, A.en
dc.contributor.authorAgnantis, N.en
dc.date.accessioned2015-11-24T19:08:49Z
dc.date.available2015-11-24T19:08:49Z
dc.identifier.issn0204-3564-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20600
dc.rightsDefault Licence-
dc.subjecthelicobacter pylorien
dc.subjectgastritisen
dc.subjectpeptic ulcer diseaseen
dc.subjectgastric canceren
dc.subjectmalt lymphomaen
dc.subjecte-cadherinen
dc.subjectadhesion moleculesen
dc.subjectpeptic-ulcer diseaseen
dc.subjectadhesion moleculesen
dc.subjectvirulence factorsen
dc.subjectexpressionen
dc.subjectcarcinomaen
dc.subjectmucosaen
dc.subjectstomachen
dc.subjectrisken
dc.titleIs the E-cadherin downregulation observed in Helicobacter pylori infection associated with gastric cancer development? An additional element in the disease jigsawen
heal.abstractAim: to investigate possible association of E-cad expression and Helicobacter pylori (HP) infection with gastrointestinal malignancy. Methods: E-cad expression was studied immunohistochemically in patients with gastrointestinal symptoms undergoing gastroduodenoscopy. Results: findings showed an association of E-cad expression with HP presence in the individuals examined. E-cad was significantly downregulated in the group of patients infected by HP. Conclusion: we conclude that downregulation of E-cad expression upon HP infection may consist an early step in the gastric cancer development, facilitating gastric epithelial cell proliferation, motility, and tumor spread.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000188745400008-
heal.journalNameExp Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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