Synthesis, characterization and in vitro study of the cytostatic and antiviral activity of new polymeric silver(I) complexes with ribbon structures derived from the conjugated heterocyclic thioamide 2-mercapto-3,4,5,6-tetrahydropyrimidine

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dc.contributor.authorZachariadis, P. C.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorSkoulika, S.en
dc.contributor.authorMichaelides, A.en
dc.contributor.authorBalzarini, J.en
dc.contributor.authorDe Clercq, E.en
dc.date.accessioned2015-11-24T16:49:29Z
dc.date.available2015-11-24T16:49:29Z
dc.identifier.issn1434-1948-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9492
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectsilveren
dc.subjectx-ray diffractionen
dc.subjectcytostatic activityen
dc.subjectantiviral activityen
dc.subjecthindered thiolate ligandsen
dc.subjectcrystal-structureen
dc.subjectmolecular-structureen
dc.subjectcopper-complexesen
dc.subjectclusteren
dc.subjectpyridine-2(1h)-thioneen
dc.subjectdihydrogenen
dc.subjectgold(i)en
dc.subjectdonorsen
dc.subjectaciden
dc.titleSynthesis, characterization and in vitro study of the cytostatic and antiviral activity of new polymeric silver(I) complexes with ribbon structures derived from the conjugated heterocyclic thioamide 2-mercapto-3,4,5,6-tetrahydropyrimidineen
heal.abstractSilver(I) bromide reacts with 2-mercapto-3,4,5,6-tetrahydropyrimidine (StpmH(2), C4H8N2S) in DMSO with an excess of triethylamine to give a water-insoluble complex of formula [Ag-6(mu(2)-Br)(6)(mu(2)-StpmH(2))(4)(mu(3)-StpmH(2))(2)](n) (1), while the reaction of silver(I) nitrate with StpmH(2) under the same conditions gives a water-insoluble complex of formula [{Ag-4(mu(2)-StpmH(2))(6)}(NO3)(4)](n) (2). The products were characterized by elemental analyses, and FT-IR far-IR, UV/Vis, H-1 and C-13 NMR spectroscopy. Crystal structures of complexes 1 and 2 were determined by X-ray diffraction. Complex 1, C24H48Ag6N12S6, crystallizes in the triclinic system space group P (1) over bar, a = 8.041(1) Angstrom, b = 12.838(4) Angstrom, c = 13.281(2) Angstrom, alpha = 68.40(1)degrees, = 72.97(1)degrees, gamma = 87.80(2), Z = 2, forming a one-dimensional infinite ribbon structure by strong interatomic interactions of two mu(2)-Br bonds with Ag(1). Complex 2, C24H48Ag4N16O12S6, crystallizes in the orthorhombic system, space group Cmc2(1), and a = 32.148(3) Angstrom, b = 9.461(2) Angstrom, c = 7.234(1) Angstrom, alpha = beta = gamma = 90degrees, Z = 8, forming infinite Ag-S-Ag chains which are bridged to each other by a sulfur atom of mu(2)-StpmH(2) ligands. Complexes 1 and 2 were studied for their cytostatic activity against murine leukemia (L1210) and human T-lymphocyte (Molt4/C8 and CEM) cells and for their antiviral activity against a wide variety of viruses. They are markedly cytostatic at 50% inhibitory concentration (IC50) values ranging from 3 to 17 mug/mL. None of the compounds showed appreciable antiviral activity at subtoxic concentrations. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1002/ejic.200300672-
heal.identifier.secondary<Go to ISI>://000220797100008-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/ejic.200300672/asset/1420_ftp.pdf?v=1&t=h0dvqj5g&s=498738d4c88cbf1f0bf69ed87f8f692068821564-
heal.journalNameEuropean Journal of Inorganic Chemistryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2004-
heal.publisherWiley-VCH Verlagen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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