Localization of metallothionein in urothelial carcinoma of the human urinary bladder: an immunohistochemical study including correlation with HLA-DR antigen, p53, and proliferation indices

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dc.contributor.authorIoachim, E. E.en
dc.contributor.authorCharchanti, A. V.en
dc.contributor.authorStavropoulos, N. E.en
dc.contributor.authorAthanassiou, E.en
dc.contributor.authorMichael, M. C.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:06:33Z
dc.date.available2015-11-24T19:06:33Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20351
dc.rightsDefault Licence-
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectAntibodies, Monoclonal/metabolismen
dc.subjectCarcinoma/*metabolismen
dc.subjectCell Divisionen
dc.subjectEpitopesen
dc.subjectFemaleen
dc.subjectHLA-DR Antigens/*biosynthesisen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMaleen
dc.subjectMetallothionein/*biosynthesis/chemistryen
dc.subjectMiddle Ageden
dc.subjectProtein Isoformsen
dc.subjectSex Factorsen
dc.subjectTumor Suppressor Protein p53/*biosynthesisen
dc.subjectUrinary Bladder Neoplasms/*metabolismen
dc.subjectUrothelium/*metabolism/pathologyen
dc.titleLocalization of metallothionein in urothelial carcinoma of the human urinary bladder: an immunohistochemical study including correlation with HLA-DR antigen, p53, and proliferation indicesen
heal.abstractMetallothionein (MT) is a low-molecular-weight cysteine-rich protein, which has the ability to bind and sequestrate heavy metal ions. Synthesis of MT is induced in a variety of tissues by these metal ions, as well as by endogenous factors such as glucocorticoids, interferon, interleukin-1 and vitamin D. Several lines of evidence show that MT may play a role in carcinogenesis. In this study MT expression was detected immunohistochemically, using a monoclonal antibody (E9) against a conserved epitope of I and II isoforms, in a series of 63 cases of urothelial carcinomas of the urinary bladder. Correlation between MT expression and HLA-DR antigen expression, p53, proliferation indices (PCNA and MIBI) as well as the various clinicopathological parameters, such as age, sex, squamous metaplasia, tumor grade, stage and recurrence were studied. In a semiquantitative analysis MT expression (> 10% of neoplastic cells) was observed in 12.7%, focal MT positivity in 11.1% and almost completely lack of MT expression in 76.2% of tumors. The incidence of MT expression was significantly higher (p=0.0002) in cases with high pathological tumor grades. MT values were significantly correlated with tumor stage (p=0.0009). A statistically significant positive correlation between MT expression and the HLA-DR antigen expression (p=0.001) was also detected. The data suggested that MT expression was correlated with a more aggressive behavior in urothelial bladder cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11497256-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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