Donor-derived breast cancer in a bone marrow transplantation recipient

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dc.contributor.authorGolfinopoulos, V.en
dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorKamakari, S.en
dc.contributor.authorMetaxa-Mariatou, V.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T19:23:45Z
dc.date.available2015-11-24T19:23:45Z
dc.identifier.issn1573-7217-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22360
dc.rightsDefault Licence-
dc.subjectAcute Diseaseen
dc.subjectAdenocarcinoma/*etiology/genetics/pathologyen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectBone Marrow Transplantation/*adverse effectsen
dc.subjectBreast Neoplasms/*etiology/genetics/pathologyen
dc.subjectCell Differentiationen
dc.subject*Cell Transformation, Neoplasticen
dc.subjectDNA, Neoplasm/geneticsen
dc.subjectEpithelial Cells/pathologyen
dc.subjectFemaleen
dc.subjectHematopoietic Stem Cells/*pathologyen
dc.subjectHumansen
dc.subjectLeukemia, Myeloid/surgeryen
dc.subjectLiving Donorsen
dc.subjectLymphatic Metastasisen
dc.subjectNeoplastic Stem Cells/*pathologyen
dc.subjectPluripotent Stem Cells/pathology/*transplantationen
dc.subjectStromal Cells/drug effects/physiology/radiation effectsen
dc.subjectTransplantation Conditioning/adverse effectsen
dc.subjectTransplantation, Homologous/*adverse effectsen
dc.titleDonor-derived breast cancer in a bone marrow transplantation recipienten
heal.abstractWe present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified radical mastectomy for invasive breast adenocarcinoma. Genetic analysis revealed chimeric cellular populations on both the tumour and normal tissues of the patient with preponderance of donor-derived cells. We conclude that the patient's epithelia had been repopulated by donor-derived hemopoietic stem cells which gave rise to a malignant mammary neoplasm several years later. The donor remains healthy to date. This case adds weight to the theory of pluripotent normal and neoplastic stem cell histogenesis and emphasizes the pivotal role of supporting host stroma in carcinogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s10549-008-9922-7-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18264757-
heal.identifier.secondaryhttp://www.springerlink.com/content/y278632tjk52l3v2/fulltext.pdf-
heal.journalNameBreast Cancer Res Treaten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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