Structural and biological studies of organotin(IV) derivatives with 2-mercapto-benzoic acid and 2-mercapto-4-methyl-pyrimidine
Φόρτωση...
Ημερομηνία
Συγγραφείς
Xanthopoulou, M. N.
Kourkoumelis, N.
Hadjikakou, S. K.
Hadjiliadis, N.
Kubicki, M.
Karkabounas, S.
Bakas, T.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Polyhedron
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Four organotin(IV) complexes with the heterocyclic thioamides 2-mercapto-4-methyl-pyrimidine hydrochloride (H2MPMT+Cl-, C5H7N2SCl) and 2-mercapto-benzoic acid (H(2)MBA, C7H6O2S), of the formulae [Ph3Sn(MPMT)] (1), [Me2Sn(MPMT)(2)] (2), {[(n-Bu)(2)Sn(MBA)](2)}(n) (3), already reported in the literature, and {[Me2Sn(MBA)](2)}n (4), with a different structure to the one already reported, have been used to study their influence upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX). The IC50 values found lie in the range 20-30 mu M. The crystal structure of 4 was determined by X-ray diffraction at room temperature (293(2) K). The structure of 4 is polymeric and it consists of {[Me2Sn(MBA)](2)} dimeric building blocks in contrast to the complex of the same formula reported earlier which has a hexameric cyclic structure. Intermolecular Sn-O bonding interactions between these units in 4 lead to the formation of infinite chains with helical conformations. In addition the crystal structure of 3, previously reported with R = 9.9%, was now reduced to R = 6.1%. Comparison with the already reported hexanuclear macrocycle complexes {[(n-Bu)(2)Sn(MBA)](6)} (5) and {[Me2Sn(MBA)](6) H2O} (6) to the helical polymeric 3 and 4 was made. DFT calculations performed for the hexameric complex 6 and helical polymeric complex 4 have shown that the energy (Delta E) difference between the two polymeric and hexanuclear conformers is only 1.65 Kcal/mol. Finally, the crystal structure of complex 2, previously solved in the orthorhombic Cmc2(1) space group, was now solved in the monoclinic P2(1)/n space group. (C) 2008 Elsevier Ltd. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
bioinorganic chemistry, organo-tin(iv) molecules, s-ligands-heterocyclic thioamides, crystal structures, helical conformation, lipoxygenase inhibition, crystal-structures, complexes, ligands, 5-chloro-2-mercaptobenzothiazole, 2-mercaptobenzothiazole, thioamides, density
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000260717700021
http://ac.els-cdn.com/S0277538708004038/1-s2.0-S0277538708004038-main.pdf?_tid=7de1c331caedd705ad293145d75d7e82&acdnat=1333030330_a13bc39525aa7cc502a1853027010e08
http://ac.els-cdn.com/S0277538708004038/1-s2.0-S0277538708004038-main.pdf?_tid=7de1c331caedd705ad293145d75d7e82&acdnat=1333030330_a13bc39525aa7cc502a1853027010e08
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας