Early pregnancy termination with vaginal misoprostol before and after 42 days gestation

dc.contributor.authorZikopoulos, K. A.en
dc.contributor.authorPapanikolaou, E. G.en
dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorTsanadis, G. D.en
dc.contributor.authorPlachouras, N. I.en
dc.contributor.authorDalkalitsis, N. A.en
dc.contributor.authorParaskevaidis, E. A.en
dc.date.accessioned2015-11-24T18:29:48Z
dc.date.available2015-11-24T18:29:48Z
dc.identifier.issn0268-1161-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/16300
dc.rightsDefault Licence-
dc.subjectabortionen
dc.subjectmisoprostolen
dc.subjectmedical pregnancy terminationen
dc.subjectearly medical abortionen
dc.subjectmifepristone ru-486en
dc.subjectillegal abortionen
dc.subjectrandomized trialen
dc.subjectmu-gen
dc.subjectmethotrexateen
dc.subjectefficacyen
dc.subjectexperienceen
dc.subjectbrazilen
dc.titleEarly pregnancy termination with vaginal misoprostol before and after 42 days gestationen
heal.abstractBackground: Misoprostol is a prostaglandin El analogue that has been used for medical abortion. We conducted this prospective study to compare the efficacy of vaginal misoprostol for abortion in women at a gestational age of <42 days and in women at a gestational age of 42-56 days. Methods: A total of 160 women seeking medical termination of a pregnancy of <56 days were enrolled in the study. Medical termination was performed using 800 mug of vaginal misoprostol, repeated every 24 h for a maximum of three doses. Results: The overall complete abortion rate was 91.3%. In group A (gestation <42 days) complete abortion occurred in 96.3% of women, whereas in group B (gestation=42-56 days) complete abortion occurred in 86.3% of women (P<0.025). The two groups did not differ significantly with respect to side-effects (incidence of pain, bleeding, nausea, diarrhoea, fever and headache). Women who had aborted successfully were significantly more satisfied with the method compared with women who did not (P<0.001). Conclusions: The vaginal misoprostol-alone regimen is highly effective for women seeking medical abortion of pregnancies of &LE;56 days. However, better efficacy may be achieved at a gestational age of <42 days.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000179839800012-
heal.identifier.secondaryhttp://humrep.oxfordjournals.org/content/17/12/3079.full.pdf-
heal.journalNameHuman Reproductionen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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