Short- and long-term elevation of autoantibody titers against oxidized LDL in patients with acute coronary syndromes - Role of the lipoprotein-associated phospholipase A(2) and the effect of atorvastatin treatment
Loading...
Date
Authors
Papathanasiou, A. I.
Lourida, E. S.
Tsironis, L. D.
Goudevenos, J. A.
Tselepis, A. D.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer reviewed
Educational material type
Conference Name
Journal name
Atherosclerosis
Book name
Book series
Book edition
Alternative title / Subtitle
Description
Oxidized low-density lipoprotein (oxLDL) is immunogenic while oxidized phospholipids (oxPL) formed on oxLDL and lysophosphatidylcholine (lyso-PC) generated during LDL oxidation through the hydrolysis of oxPL by the lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), significantly contribute to oxLDL immunogenicity. We determined the autoantibody titers against various forms of mildly oxLDL in patients with acute coronary syndromes without persistent elevation of the ST segment (NSTE-ACS) and with undetectable serum levels of lipoprotein (a). Moreover, the effect of early atorvastatin administration on these autoantibody titers was evaluated. From the 133 consecutive NSTE-ACS patients, 55 were eligible for the study. Thirty-four received atorvastatin (group A), whereas 21 did not received any hypolipdemic therapy (group B). Two forms of copper-oxidized LDL were prepared at the end of propagation or decomposition phase (oxLDL(P) or oxLDL(D), respectively). Similar types of oxLDL were prepared after previous inactivation of the endogenous Lp-PLA(2) [oxLDL(-)]. In group B, autoantibody titers of IgG class against oxLDL(P) and oxLDL(D) were elevated at 1 month of follow-up to reach the baseline values 3 months afterwards. By contrast the titers against oxLDL(-)(P) and oxLDL(-)(D) increased at 1 month of follow-up and remained elevated for up to 6 months of follow-up. Atorvastatin treatment prevented the elevation of autoantibody titers against all forms of oxidized LDL. We conclude that a short-term immune response against oxLDL(P) and oxLDLD (enriched in lyso-PC) and a chronic immune response against oxLDL(-)(P) and oxLDL(-)(D) (enriched in oxPL) are observed after an NSTE-ACS, suggesting an important role of the LDL-associated Lp-PLA(2) in modulating these immune responses. Early atorvastatin treatment prevents both immune responses; however, the clinical significance of this effect remains to be established. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
Description
Keywords
oxidation, atherosclerosis, lipoproteins, atorvastain, autoantibodies, lipoprotein-associated phospholipase a(2), paf-acetylhydrolase, low-density-lipoprotein, activating factor-acetylhydrolase, artery-disease, paf-acetylhydrolase, degrading acetylhydrolase, oxidative modification, phospholipids, hypercholesterolemia, atherosclerosis, antioxidants
Subject classification
Citation
Link
<Go to ISI>://000253341500037
http://ac.els-cdn.com/S0021915006006708/1-s2.0-S0021915006006708-main.pdf?_tid=906fa7d02083fe92597e539ce538a431&acdnat=1333111724_def0539fea8ea48a79b9a803c0d944bf
http://ac.els-cdn.com/S0021915006006708/1-s2.0-S0021915006006708-main.pdf?_tid=906fa7d02083fe92597e539ce538a431&acdnat=1333111724_def0539fea8ea48a79b9a803c0d944bf
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας