Monte-Carlo study of energy deposition by heavy charged particles in sub-cellular volumes
| dc.contributor.author | Emfietzoglou, D. | en |
| dc.contributor.author | Papamichael, G. | en |
| dc.contributor.author | Pathak, A. | en |
| dc.contributor.author | Fotopoulos, A. | en |
| dc.contributor.author | Nikjoo, H. | en |
| dc.date.accessioned | 2015-11-24T19:03:49Z | |
| dc.date.available | 2015-11-24T19:03:49Z | |
| dc.identifier.issn | 0144-8420 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19935 | |
| dc.rights | Default Licence | - |
| dc.subject | Cell Physiological Phenomena/*radiation effects | en |
| dc.subject | Computer Simulation | en |
| dc.subject | DNA/*genetics/*radiation effects | en |
| dc.subject | *Heavy Ions | en |
| dc.subject | *Linear Energy Transfer | en |
| dc.subject | *Models, Biological | en |
| dc.subject | Monte Carlo Method | en |
| dc.subject | Protons | en |
| dc.subject | Radiation Dosage | en |
| dc.subject | Radiometry/*methods | en |
| dc.title | Monte-Carlo study of energy deposition by heavy charged particles in sub-cellular volumes | en |
| heal.abstract | Detailed-history Monte-Carlo code is used to study the energy deposition from proton and alpha particle tracks at the sub-cellular level. Inelastic cross sections for both the vapour and liquid phases of water have been implemented into the code in order to explore the influence of non-linear density effects associated with the condensed-phase cellular environment. Results of energy deposition and its straggling for 0.5 to 5 MeV amu(-1) protons and alpha particles traversing or passing near spherical volumes of 2-200 nm in diameter relevant to DNA- and chromosome-size targets are presented. It is shown that the explicit account of delta-ray transport reduces the dose by as much as 10-60%, whereas stochastic fluctuations lead to a relative uncertainty ranging from 20% to more than 100%. Protons and alpha particles of the same velocity exhibit a similar delta-ray effect, whereas the relative uncertainty of the alphas is almost half that of protons. The effect of the phase is noticeable (10-15%) mainly through differences on the transport of delta-rays, which in liquid water have higher penetration distances. It is expected that the implementation of such results into multi-scale biophysical models of radiation effects will lead to a more realistic predictions on the efficacy of new radiotherapeutic modalities that employ either external proton beam irradiation or internal alpha-emitting radionuclides. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1093/rpd/ncm092 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17513851 | - |
| heal.identifier.secondary | http://rpd.oxfordjournals.org/content/126/1-4/457.full.pdf | - |
| heal.journalName | Radiat Prot Dosimetry | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2007 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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