(99m)Tc-Tetrofosmin brain SPECT in the assessment of meningiomas-correlation with histological grade and proliferation index

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dc.contributor.authorFotopoulos, A. D.en
dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorGoussia, A.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorPolyzoidis, K. S.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorTsiouris, S.en
dc.date.accessioned2015-11-24T19:40:54Z
dc.date.available2015-11-24T19:40:54Z
dc.identifier.issn0167-594X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24418
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectBrain/metabolism/*radionuclide imagingen
dc.subjectCell Proliferationen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectKi-67 Antigen/metabolismen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMeningeal Neoplasms/pathology/*radionuclide imagingen
dc.subjectMeningioma/pathology/*radionuclide imagingen
dc.subjectMiddle Ageden
dc.subjectRetrospective Studiesen
dc.subjectStatistics as Topicen
dc.subjectTechnetium Tc 99m Sestamibi/*diagnostic useen
dc.subject*Tomography, Emission-Computed, Single-Photonen
dc.title(99m)Tc-Tetrofosmin brain SPECT in the assessment of meningiomas-correlation with histological grade and proliferation indexen
heal.abstractMeningiomas account for about 30% of all intracranial tumors. Evaluation of their proliferation rate is useful for assessing their biological behavior. We evaluated prospectively whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake in meningiomas correlates with cellular proliferative activity and with tumor grade. We prospectively studied 18 meningioma cases. Brain single-photon emission computed tomography (SPECT) by (99m)Tc-TF was performed within a week prior to surgical excision. In the excised tumor specimens we assessed Ki-67 antigen expression. 14 of 18 patients had benign meningiomas, while the remaining four had anaplastic meningiomas. A significant correlation was found between both (99m)Tc-TF uptake and tumor grade (r = 0.722, P = 0.001) and between (99m)Tc-TF uptake and Ki-67 expression (r = 0.930, P < 0.001). There was a significant correlation between the intensity of tracer uptake and tumor recurrence at 1 year postoperative (r = 0.574, P = 0.02). This pilot study implies that (99m)Tc-TF brain SPECT could prove useful in differentiating benign from anaplastic meningiomas and is a potential indicator of their proliferative activity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s11060-008-9611-8-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18458817-
heal.identifier.secondaryhttp://www.springerlink.com/content/l682w40l16tv7g63/fulltext.pdf-
heal.journalNameJ Neurooncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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