Selective decontamination of subglottic area in mechanically ventilated patients with multiple trauma
| dc.contributor.author | Pneumatikos, I. | en |
| dc.contributor.author | Koulouras, V. | en |
| dc.contributor.author | Nathanail, C. | en |
| dc.contributor.author | Goe, D. | en |
| dc.contributor.author | Nakos, G. | en |
| dc.date.accessioned | 2015-11-24T18:52:37Z | |
| dc.date.available | 2015-11-24T18:52:37Z | |
| dc.identifier.issn | 0342-4642 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18417 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Antibiotic Prophylaxis/*methods | en |
| dc.subject | Bacterial Infections/prevention & control | en |
| dc.subject | Chi-Square Distribution | en |
| dc.subject | Cross Infection/prevention & control | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Multiple Trauma/*therapy | en |
| dc.subject | Pneumonia, Bacterial/etiology/*prevention & control | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Respiration, Artificial/*adverse effects | en |
| dc.subject | Trachea/microbiology | en |
| dc.title | Selective decontamination of subglottic area in mechanically ventilated patients with multiple trauma | en |
| heal.abstract | OBJECTIVE: To determine whether selective decontamination locally in the subglottic area (SDSA) reduces tracheal colonization and prevents ventilator-associated pneumonia (VAP) in patients with multiple trauma. DESIGN AND SETTING: A prospective randomized, controlled, clinical study in a 14-bed general intensive care unit of a university hospital. PATIENTS: 79 consecutive multiple trauma patients admitted to the ICU who were expected to be mechanically ventilated for more than 5 days; 61 patients completed the protocol. INTERVENTION: Patients were randomly assigned to receive SDSA using a continuous infusion of a suspension containing three nonabsorbable antibiotics (polymyxin, tombramycin, and amphotericin B; n=30) or placebo ( n=31). MEASUREMENTS: The incidence of bronchial and gastric colonization and the number of cases of VAP were recorded. Gastric fluid and tracheal secretion cultures were obtained soon after intubation and thereafter every 4 days. Etiological diagnosis of VAP was based on samples taken by a specific protected double catheter set. RESULTS: VAP developed in 5 of 30 (16.6%) patients receiving SDSA and 16 of 31 (51.6%) patients receiving placebo. Negative bronchial secretion cultures were found in 14 of 30 (46.6%) patients in the SDSA group and in only 3 of 31 (9.6%) patients in the control group. No patient with negative bronchial secretion culture developed VAP. No significant differences in outcome were found. CONCLUSIONS: The SDSA is an effective and safe type of chemoprophylaxis against tracheal colonization and can significantly reduce the incidence of VAP in mechanically ventilated patients with multiple trauma. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s00134-002-1238-1 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11967597 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/pf9rwty1wt4j0nyk/fulltext.pdf | - |
| heal.journalName | Intensive Care Med | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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