Morphologic differences between latent membrane protein-1 (LMP-1)-positive and negative tumour cells in Epstein-Barr virus (EBV)-related childhood Hodgkin's disease. A morphometric study

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dc.contributor.authorPanayiotides, J.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorProtopapa, E.en
dc.contributor.authorVlachonikolis, J.en
dc.contributor.authorTzardi, M.en
dc.contributor.authorKalmanti, M.en
dc.contributor.authorDelides, G.en
dc.date.accessioned2015-11-24T19:03:45Z
dc.date.available2015-11-24T19:03:45Z
dc.identifier.issn0344-0338-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19928
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectHerpesviridae Infections/metabolism/*pathologyen
dc.subject*Herpesvirus 4, Humanen
dc.subjectHodgkin Disease/metabolism/*pathology/*virologyen
dc.subjectHumansen
dc.subjectTumor Virus Infections/metabolism/*pathologyen
dc.subjectViral Matrix Proteins/*analysisen
dc.titleMorphologic differences between latent membrane protein-1 (LMP-1)-positive and negative tumour cells in Epstein-Barr virus (EBV)-related childhood Hodgkin's disease. A morphometric studyen
heal.abstractThe values of five cellular morphometric parameters (longest and shortest cytoplasmic axis, cellular circumference, area and roundness coefficient) were compared between 20 Latent Membrane Protein 1 (LMP-1)-positive and an equal number of LMP-1-negative Reed-Sternberg and Hodgkin (HRS) cells for each of 13 cases of Hodgkin's disease (HD) occurring in children (aged 3-15 years); the presence of Epstein-Barr virus (EBV) encoded EBER mRNAs had previously been detected in all cases using RNA in situ hybridisation (RISH), while the presence of LMP-1 was immunohistochemically detected using the alkaline phosphatase-antialkaline phosphatase (APAAP) method. The longest and shortest axis, circumference and area were larger in LMP-1-positive than in LMP-1 negative HRS cells, while the roundness coefficient of LMP-positive HRS cells was smaller than that of LMP-1 negative cells. All differences were statistically highly significant when univariate (paired comparisons) t-test were used. Multivariate analysis (Hotelling's T2 test) showed all differences (except the roundness coefficient) to be significant both at the 5% and 1% level of significance. These results provide a numerical basis for the alteration brought by the expression of LMP-1 in the cellular skeleton of tumour (HRS) cells in EBV-related childhood HD cases.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8739467-
heal.journalNamePathol Res Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1996-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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