Synthesis, characterization and biological activity of antimony(III) or bismuth(III) chloride complexes with dithiocarbamate ligands derived from thiuram degradation

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dc.contributor.authorI.I. Ozturken
dc.contributor.authorC.N. Bantien
dc.contributor.authorN. Kourkoumelisen
dc.contributor.authorM.J. Manosen
dc.contributor.authorA.J. Tasiopoulosen
dc.contributor.authorA.M. Owczarzaken
dc.contributor.authorM. Kubickien
dc.contributor.authorS.K. Hadjikakouen
dc.date.accessioned2015-11-24T16:49:24Z
dc.date.available2015-11-24T16:49:24Z
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9480
dc.rightsDefault Licence-
dc.subjectBioinorganic chemistryen
dc.subjectAntimony(III) and bismuth(III) complexesen
dc.subjectPolymorphsen
dc.subjectStructure activity relationship (SAR)en
dc.subjectCytotoxicityen
dc.subjectPCAen
dc.subjectMolecular dockingen
dc.titleSynthesis, characterization and biological activity of antimony(III) or bismuth(III) chloride complexes with dithiocarbamate ligands derived from thiuram degradationen
heal.abstractAntimony(III) or bismuth(III) complexes of formulae {[SbCl(Me2DTC)2]n} (1), {[BiCl(Me2DTC)2]n} (2) and {[Bi(Et2DTC)3]2} (3) (Me2DTCH = dimethyldithiocarbamate, C3H7NS2 and Et2DTCH = diethyldithiocarbamate, C5H11NS2) were isolated from the reactions between SbCl3 or BiCl3 with tetramethylthiuram monosulfide (Me4tms), tetramethylthiuram disulfide (Me4tds) or tetraethylthiuram disulfide (Et4tds). In the case of 1 two polymorphs were isolated depending on the synthetic procedure followed. Crystal growth from the reaction of antimony(III)-chloride with Me4tms in methanol produced 1a polymorph, while those derived from Me4tds in acetonitrile/dichloromethane produced 1b form. The complexes 1-3 were characterized by m.p., e.a., FT-IR, FT-Raman, 1H, 13C NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TGA-DTA). Moreover, single crystal X-ray diffraction analysis was carried out for 1a, 1b, 2 and 3. X-ray powder diffraction data confirm the existence of one polymorph in the bulk of each sample of 1a and 1b. 1H NMR spectra in the DMSO-d6 solutions of 1a and 1b suggest the retention of the structural variations. Complexes 1 and 2 are polymers with distorted square pyramidal (SPY) geometry in each monomeric unit. The known structure of 3 was re-determined to be used for the theoretical and structure activity relationship studies (SAR). Complexes 1-3 were evaluated for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervix adenocarcinoma (HeLa) cells. Complex 3 is more active against HeLa cells whereas 1a, 1b and 2 against MCF-7. Compound 1a shows slightly higher activity than 1b. Principal components analysis (PCA) was performed to discriminate the significant physicochemical molecular descriptors while regression analysis successfully related the experimental inhibitory concentration, (IC50) to the independent variables indexed by PCA. The calculated IC50 values are satisfactorily compared with the measured inhibitory activity of the complexes.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryhttp://dx.doi.org/10.1016/j.poly.2013.08.052-
heal.identifier.secondaryhttp://www.sciencedirect.com/science/article/pii/S0277538713006232#-
heal.journalNamePolyhedronen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2014-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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