Epidermal growth factor receptor expression in primary laryngeal cancer: An independent prognostic factor of neck node relapse

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dc.contributor.authorAlmadori, G.en
dc.contributor.authorCadoni, G.en
dc.contributor.authorGalli, J.en
dc.contributor.authorFerrandina, G.en
dc.contributor.authorScambia, G.en
dc.contributor.authorExarchakos, G.en
dc.contributor.authorPaludetti, G.en
dc.contributor.authorOttaviani, F.en
dc.date.accessioned2015-11-24T19:18:51Z
dc.date.available2015-11-24T19:18:51Z
dc.identifier.issn0020-7136-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21904
dc.rightsDefault Licence-
dc.subjectsquamous-cell carcinomasen
dc.subjectdissectionen
dc.subjectsurvivalen
dc.titleEpidermal growth factor receptor expression in primary laryngeal cancer: An independent prognostic factor of neck node relapseen
heal.abstractSpecimens of laryngeal squamous cell carcinoma (LSCC) were examined for epidermal growth factor receptor (EGFR) content using a radioreceptor method; 140 untreated consecutive patients with primary LSCC undergoing initial surgical resection were followed up for a median of 49 months (range 2-84 months) after surgery. Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels were directly associated with the risk of lymph node metastasis, A significant relationship between EGFR status and cervical node metastasis was observed. The cutoff value of 20 fmol/mg protein was the best prognostic discriminator. The 5-year metastasis-free survival (MFS) was 66% for patients with EGFR(-) tumors compared with 15% for patients with EGFR(+) tumors. By multivariate analysis, the EGFR status appeared to be a significant independent prognostic factor for MFS. Our results suggest that the assessment of EGFR status at the time of diagnosis may identify a subset of LSCC patients highly susceptible to neck node metastases thus defining therapy accordingly. Int. J. Cancer (Pred. Oncol.) 84:188-191, 1999. in 1999 Wiley-Liss, Inc.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000079167700016-
heal.journalNameInternational Journal of Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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