Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI
| dc.contributor.author | Tzarouchi, L. C. | en |
| dc.contributor.author | Xydis, V. | en |
| dc.contributor.author | Zikou, A. K. | en |
| dc.contributor.author | Drougia, A. | en |
| dc.contributor.author | Astrakas, L. G. | en |
| dc.contributor.author | Papastefanaki, M. | en |
| dc.contributor.author | Andronikou, S. | en |
| dc.contributor.author | Argyropoulou, M. I. | en |
| dc.date.accessioned | 2015-11-24T19:24:22Z | |
| dc.date.available | 2015-11-24T19:24:22Z | |
| dc.identifier.issn | 1432-1998 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22464 | |
| dc.rights | Default Licence | - |
| dc.title | Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI | en |
| heal.abstract | BACKGROUND: Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL). OBJECTIVE: Evaluate changes in the volume of 116 GM areas in preterm children with dPVL. METHODS AND MATERIALS: Eleven preterm children with dPVL, gestational age 32.8 +/- 2.6 weeks, examined at corrected age 22.0 +/- 18.2 months and 33 matched preterm controls with normal brain MRI were studied. Volumes of 116 individual GM areas, and white matter/cerebrospinal fluid (WM/CSF) ratio were calculated on T1-weighted high-resolution images after segmentation. RESULTS: Relative to controls, children with dPVL had decreased GM volume of the hippocampus, amygdala, and frontal lobes and temporal middle gyrus (P < 0.05); increased GM volume of the putamen, thalamus, globus pallidum, superior temporal gyrus and of the parietal and occipital lobes (P < 0.05) and lower WM volume/higher CSF volume (P < 0.05). WM/CSF ratios also differed (P < 0.05). CONCLUSIONS: Preterm children with dPVL have increased regional GM volume in some areas probably related with a process of brain plasticity-regeneration and reduced GM volume in areas associated with cognition and memory. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s00247-011-2223-z | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21901522 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/fu827687uqk2jg81/fulltext.pdf | - |
| heal.journalName | Pediatric Radiology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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