Abnormal immunological development in fetuses with trisomy 18
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Plachouras, N. | en |
| dc.contributor.author | Thilaganathan, B. | en |
| dc.contributor.author | Nicolaides, K. H. | en |
| dc.date.accessioned | 2015-11-24T19:38:42Z | |
| dc.date.available | 2015-11-24T19:38:42Z | |
| dc.identifier.issn | 0197-3851 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24172 | |
| dc.rights | Default Licence | - |
| dc.subject | B-Lymphocytes/physiology | en |
| dc.subject | *Chromosomes, Human, Pair 18 | en |
| dc.subject | Embryonic and Fetal Development/immunology | en |
| dc.subject | Fetal Blood | en |
| dc.subject | Humans | en |
| dc.subject | Killer Cells, Natural/physiology | en |
| dc.subject | Leukocyte Count | en |
| dc.subject | T-Lymphocytes/physiology | en |
| dc.subject | Trisomy/*immunology | en |
| dc.title | Abnormal immunological development in fetuses with trisomy 18 | en |
| heal.abstract | Flow cytometry was used to enumerate the lymphocyte subpopulations in fetal blood obtained by cordocentesis from eight trisomy 18 fetuses at 20-36 weeks' gestation. Compared with values in chromosomally normal fetuses, in trisomy 18 the mean T- and natural killer (NK) cell counts were significantly lower (t = -7.63, P < 0.001 and t = -3.58, P < 0.01, respectively); the mean B-cell count was not significantly different (t = -1.32). These findings demonstrate that in trisomy 18 there is abnormal intrauterine development of the immune system. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8066033 | - |
| heal.journalName | Prenat Diagn | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1994 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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