Neurokinin receptor 1-expressing spinal cord neurons in lamina I and III/IV of postnatal rats receive inputs from capsaicin sensitive fibers
| dc.contributor.author | Labrakakis, C. | en |
| dc.contributor.author | MacDermott, A. B. | en |
| dc.date.accessioned | 2015-11-24T16:33:03Z | |
| dc.date.available | 2015-11-24T16:33:03Z | |
| dc.identifier.issn | 0304-3940 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7612 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Animals, Newborn | en |
| dc.subject | Capsaicin/*pharmacology | en |
| dc.subject | Excitatory Postsynaptic Potentials/drug effects/physiology | en |
| dc.subject | Nerve Fibers/chemistry/drug effects/*metabolism | en |
| dc.subject | Posterior Horn Cells/chemistry/drug effects/*metabolism | en |
| dc.subject | Rats | en |
| dc.subject | Receptors, Neurokinin-1/analy | en |
| dc.title | Neurokinin receptor 1-expressing spinal cord neurons in lamina I and III/IV of postnatal rats receive inputs from capsaicin sensitive fibers | en |
| heal.abstract | Dorsal horn neurons expressing receptor for substance P (SP), the neurokinin 1 (NK1) receptor, play an important role in transmission and processing of nociceptive stimuli. To identify and study these neurons in the rat spinal cord slice preparation, we used fluorescence-conjugated SP to label NK1 receptor-expressing neurons. Labeled neurons in lamina I and III/IV were patch clamped and the vanilloid receptor 1 (TRPV1) agonist, capsaicin, was applied to evoke glutamate release from central terminals of peripheral nociceptors. Capsaicin induced an increase in the frequency of miniature excitatory postsynaptic currents in 73% of lamina I and 43% of lamina III/IV neurons expressing NK1-receptor indicating that these neurons receive direct input from capsaicin and heat sensitive nociceptors. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/14625038 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0304394003010358/1-s2.0-S0304394003010358-main.pdf?_tid=1a8d6248-c388-11e2-85d1-00000aacb35d&acdnat=1369300190_f51b8b1a5968f587eb76dd7a6996ce1d | - |
| heal.journalName | Neurosci Lett | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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