Electrophysiologic effects of endothelin receptor-A blockade in patients with coronary artery disease
Loading...
Date
Authors
Kolettis, T. M.
Kyriakides, Z. S.
Leftheriotis, D.
Papalambrou, A.
Kremastinos, D. T.
Webb, D. J.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
J Interv Card Electrophysiol
Book name
Book series
Book edition
Alternative title / Subtitle
Description
Selective endothelin receptor-A antagonists are a promising new treatment in patients with heart failure and/or pulmonary hypertension. Animal studies have suggested that these agents may have additional cardiac electrophysiologic actions, however, no data exist in man. We examined the effects of acute endothelin receptor-A blockade on the sinus node, the atrioventricular node and on the ventricular myocardium, in patients with single-vessel coronary artery disease and preserved left ventricular function. The selective endothelin receptor-A antagonist BQ-123 was administered by the intracoronary route, in order to achieve maximum local cardiac effects. After endothelin receptor-A blockade, QT interval increased from 373 +/- 30 msec (mean +/- SD) to 395 +/- 20 msec (p < 0.01) and QTc interval increased from 394 +/- 36 msec to 421 +/- 28 msec (p < 0.01). QT-dispersion, calculated from 12-lead ECG, decreased from 40 +/- 18 msec to 24 +/- 8 msec (p < 0.01) and QTc-dispersion decreased from 44 +/- 20 msec to 26 +/- 9 msec (p < 0.05). These changes were evident only after infusion in the left, but not in the right coronary artery. No effect was found on the sinus node, the atrioventricular node, or the ventricular effective refractory periods. We conclude that selective endothelin receptor A blockade lengthens ventricular repolarization and decreases its inhomogeneity. Further studies are needed to evaluate possible antiarrhythmic actions of this class of agent.
Description
Keywords
Aged, Atrioventricular Node/physiopathology, Coronary Artery Disease/*drug therapy/*physiopathology, Coronary Vessels, *Electrocardiography, Female, Humans, Infusions, Intra-Arterial, Male, Middle Aged, Peptides, Cyclic/*administration & dosage, Receptor, Endothelin A/*antagonists & inhibitors, Sinoatrial Node/physiopathology, Sodium Chloride/administration & dosage
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/12815302
http://www.springerlink.com/content/v86x53l4348l2923/fulltext.pdf
http://www.springerlink.com/content/v86x53l4348l2923/fulltext.pdf
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής