The immunohistochemical expression of metallothionein in inflammatory bowel disease. Correlation with HLA-DR antigen expression, lymphocyte subpopulations and proliferation-associated indices

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dc.contributor.authorIoachim, E.en
dc.contributor.authorMichael, M.en
dc.contributor.authorKatsanos, C.en
dc.contributor.authorDemou, A.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T19:41:08Z
dc.date.available2015-11-24T19:41:08Z
dc.identifier.issn0213-3911-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24448
dc.rightsDefault Licence-
dc.subjectAntigens, CD/metabolismen
dc.subjectAntigens, Differentiation, Myelomonocytic/metabolismen
dc.subjectCell Divisionen
dc.subjectEpithelium/metabolismen
dc.subjectFemaleen
dc.subjectHLA-DR Antigens/*metabolismen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectInflammatory Bowel Diseases/*metabolismen
dc.subjectIntestine, Large/metabolismen
dc.subjectLymphocyte Subsets/*metabolismen
dc.subjectMaleen
dc.subjectMetallothionein/*metabolismen
dc.subjectMiddle Ageden
dc.titleThe immunohistochemical expression of metallothionein in inflammatory bowel disease. Correlation with HLA-DR antigen expression, lymphocyte subpopulations and proliferation-associated indicesen
heal.abstractMetallothionein (MT) expression in intestinal resection specimens from 41 patients with ulcerative colitis (UC) and 10 patients with Crohn's disease (CD ) was immunohistochemically studied by the avidin-biotin (ABC) method. In addition, the possible relationship of its expression with HLA-DR antigen expression, lymphocyte subpopulations and proliferation-associated indices was studied in order to elucidate the role of this molecule in inflammatory bowel disease (IBD). The MT immunoreactivity was recorded by staining and intensity-distribution scores. MT staining varied in and was mainly localized in the cytoplasm, although a combined nuclear/cytoplasmic reactive pattern was also seen in epithelial cells. MT expression was decreased in UC, and CD compared with normal mucosa. No difference in MT expression between UC and CD was noted. In UC, a gradually decreased expression from remission, to resolving and to active phase was observed. An inverse correlation of MT expression with HLA-DR antigen expression was detected (p = 0.018) in the cases of UC. The data suggest that a low level of MT expression in inflammatory bowel disease and particularly in active phase of UC may indicate a decreased endogenous intestinal protection and it may be implicated in the pathogenesis of the disease.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12507286-
heal.journalNameHistol Histopatholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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