Low gestational age and chronic lung disease are synergistic risk factors for retinopathy of prematurity
Φόρτωση...
Ημερομηνία
Συγγραφείς
Giapros, V.
Drougia, A.
Asproudis, I.
Theocharis, P.
Andronikou, S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Early Hum Dev
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
AIMS: This retrospective, population based study was designed to investigate risk factors for development of retinopathy of prematurity (ROP) and their possible interrelationships, in neonates of gestational age (GA) <32 weeks born in a well-defined geographical region. STUDY DESIGN-SUBJECTS: The study population included all preterm infants born alive with GA 24-32 weeks in Northwestern Greece during a 9-year period and hospitalised in the regional neonatal intensive care unit (NICU). OUTCOME MEASUREMENTS: The association was assessed of the presence of ROP with maternal factors: age, pathology of pregnancy, in-vitro fertilisation, multiple gestation, mode of delivery, perinatal factors: gender, antenatal steroids, transportation, resuscitation, GA, birth weight (BW), small for GA status and postnatal morbidity: chronic lung disease (CLD), intraventricular haemorrhage (IVH), necrotizing enterocolitis (NEC), respiratory distress syndrome (RDS), maximum O(2) needs, hypoxic/hyperoxic episodes, patent ductus arteriosus (PDA), sepsis, using multiple logistic regression analysis. RESULTS: Of 189 infants without congenital anomalies born at GA 24-32 weeks ROP was diagnosed in 24 (12.7%) (>grade 2: 6). Logistic regression analysis showed ROP to be strongly associated with GA, odds ratio (OR) 2.1, confidence interval (CI) 1.3-3.3, p<0.01 and CLD, OR 10.2, CI 2.3-44, p<0.01, respectively, independent of confounding factors. By estimating interaction on an additive scale it was shown that the combined risk effect of GA and CLD was larger than the sum of the individual risk effects, implying synergistic effect. CONCLUSIONS: ROP was closely and independently related to both low GA and the diagnosis of CLD, which were interrelated in the development of ROP.
Περιγραφή
Λέξεις-κλειδιά
Adult, Chronic Disease, Ductus Arteriosus, Patent, Enterocolitis, Necrotizing/epidemiology, Female, Gestational Age, Greece, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases/epidemiology, Intensive Care Units, Neonatal, Lung Diseases/*complications/epidemiology, Male, Maternal Age, Pregnancy, Pregnancy Complications/epidemiology, Pregnancy, Multiple, Respiratory Distress Syndrome, Newborn, Retinopathy of Prematurity/*epidemiology/*etiology, Retrospective Studies, Risk Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21621351
http://ac.els-cdn.com/S0378378211001861/1-s2.0-S0378378211001861-main.pdf?_tid=e443788e08b6a3c3d8f5f3718831d395&acdnat=1332917042_da8421e72e79ca778fd04603ad5f5898
http://ac.els-cdn.com/S0378378211001861/1-s2.0-S0378378211001861-main.pdf?_tid=e443788e08b6a3c3d8f5f3718831d395&acdnat=1332917042_da8421e72e79ca778fd04603ad5f5898
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής