Frequency, clinical characteristics, and genotype distribution of rotavirus gastroenteritis in Greece (2007-2008)
Φόρτωση...
Ημερομηνία
Συγγραφείς
Koukou, D.
Grivea, I.
Roma, E.
Tsioni, H.
Trimis, G.
Galanakis, E.
Farmaki, E.
Iosifidis, E.
Michos, A.
Siamopoulou-Mavridou, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Med Virol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Rotavirus is the leading cause of acute gastroenteritis among young children worldwide. A prospective multi-center study was conducted (2007-2008) in five Pediatric Hospitals to determine the prevalence, the clinical characteristics, and genotype distribution of rotavirus infection in Greece. Faecal samples were examined for the presence of group A rotavirus antigen by immunochromatography. Rotavirus strains were subjected to G and P genotyping by reverse-transcriptase polymerase chain reaction (PCR) and sequencing. A total of 393 children (216 boys) of median age 23 months, participated in the study. Rotavirus was the cause of acute gastroenteritis in 166 children, 42.3% (CI 95%, 37.4-47.1%) of non-hospitalized and 47.8% (CI 95%, 41.7-53.9%) of hospitalized patients. Rotavirus gastroenteritis occurred between December and April in 78.6% of the cases. Most children with RVG (77.8%) were between 3 months and 3 years old. The mean value of Clark severity score was 12.9 +/- 5.1 for RVG and 10.5 +/- 4.9 for non-RVG (P < 0.01). Genotypes were determined in 117 strains and their distribution was as following: G1P[8], 49%; G2P[4], 31%; G4P[8], 10%; G9P[8], 9%; and G8P[14], 1%. In conclusion, rotavirus is a frequent cause of acute gastroenteritis in Greece. The genotypes circulating are similar with those of other European countries.
Περιγραφή
Λέξεις-κλειδιά
Antigens, Viral/analysis, Child, Preschool, Feces/virology, Female, Gastroenteritis/*epidemiology/pathology/*virology, Genotype, Greece/epidemiology, Humans, Infant, Male, Prevalence, Prospective Studies, RNA, Viral/genetics, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus/*classification/*genetics/isolation & purification, Rotavirus Infections/*epidemiology/pathology/*virology, Sequence Analysis, DNA
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21108355
http://onlinelibrary.wiley.com/store/10.1002/jmv.21945/asset/21945_ftp.pdf?v=1&t=h0c6t7gj&s=27a62dccb25b4cd06522fb9132f0792656d828e2
http://onlinelibrary.wiley.com/store/10.1002/jmv.21945/asset/21945_ftp.pdf?v=1&t=h0c6t7gj&s=27a62dccb25b4cd06522fb9132f0792656d828e2
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής