The lamin B receptor-associated protein p34 shares sequence homology and antigenic determinants with the splicing factor 2-associated protein p32
| dc.contributor.author | Simos, G. | en |
| dc.contributor.author | Georgatos, S. D. | en |
| dc.date.accessioned | 2015-11-24T19:38:29Z | |
| dc.date.available | 2015-11-24T19:38:29Z | |
| dc.identifier.issn | 0014-5793 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24153 | |
| dc.rights | Default Licence | - |
| dc.subject | Amino Acid Sequence | en |
| dc.subject | Animals | en |
| dc.subject | Binding Sites | en |
| dc.subject | Epitopes/chemistry | en |
| dc.subject | Erythrocytes/chemistry | en |
| dc.subject | Membrane Proteins/*chemistry/immunology/isolation & purification | en |
| dc.subject | Molecular Sequence Data | en |
| dc.subject | Molecular Weight | en |
| dc.subject | Nuclear Proteins/*chemistry/immunology/isolation & purification | en |
| dc.subject | RNA-Binding Proteins | en |
| dc.subject | Receptors, Cytoplasmic and Nuclear/*chemistry | en |
| dc.subject | Sequence Homology, Amino Acid | en |
| dc.subject | Turkeys/blood | en |
| dc.title | The lamin B receptor-associated protein p34 shares sequence homology and antigenic determinants with the splicing factor 2-associated protein p32 | en |
| heal.abstract | The lamin B receptor (p58) is an inner nuclear membrane protein that forms an in vivo complex with the nuclear lamins, a nuclear envelope kinase, and two other nuclear proteins with apparent M(r) of 18,000 (p18) and 34,000 (p34). We now report the isolation of p34 by partial dissociation of the immunoaffinity-purified p58 protein complex. Determination of the N-terminal amino acid sequence of purified p34 shows that this polypeptide is homologous to p32, a splicing factor 2 (SF2)-associated protein. The relatedness between p34 and p32 can be further established by showing that antibodies raised against N- and C-terminal peptides of p32 cross-react with purified p34. As the amino acid sequence of p58 contains an arginine/serine (RS)-rich region similar to the RS-rich region found in SF 2, we speculate that these domains provide binding sites for p34 and that this protein may be a linker between the nuclear membrane and intranuclear spliceosomal substructures. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7516896 | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/001457939400479X | - |
| heal.journalName | FEBS Lett | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1994 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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