Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments

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dc.contributor.authorDjabali, K.en
dc.contributor.authorPortier, M. M.en
dc.contributor.authorGros, F.en
dc.contributor.authorBlobel, G.en
dc.contributor.authorGeorgatos, S. D.en
dc.date.accessioned2015-11-24T19:02:22Z
dc.date.available2015-11-24T19:02:22Z
dc.identifier.issn0092-8674-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19793
dc.rightsDefault Licence-
dc.subjectAmino Acid Sequenceen
dc.subjectAnimalsen
dc.subjectCell Lineen
dc.subjectCell Nucleus/physiology/*ultrastructureen
dc.subjectCells, Cultureden
dc.subjectEmbryo, Mammalianen
dc.subjectEmbryo, Nonmammalianen
dc.subjectErythrocytes/physiology/*ultrastructureen
dc.subjectFluorescent Antibody Techniqueen
dc.subjectImmunoblottingen
dc.subjectIntermediate Filament Proteins/genetics/*metabolismen
dc.subjectIntermediate Filaments/physiology/*ultrastructureen
dc.subjectKineticsen
dc.subjectLamin Type Ben
dc.subjectLaminsen
dc.subject*Membrane Glycoproteinsen
dc.subjectMiceen
dc.subjectMicrosomes, Liver/physiology/*ultrastructureen
dc.subjectMitochondria, Liver/physiology/*ultrastructureen
dc.subjectMolecular Sequence Dataen
dc.subject*Nerve Tissue Proteinsen
dc.subjectNeuroblastomaen
dc.subjectNeurons/physiology/*ultrastructureen
dc.subjectNeuropeptides/metabolismen
dc.subjectNuclear Proteins/*metabolismen
dc.subjectProtein Bindingen
dc.subjectRatsen
dc.subjectRestriction Mappingen
dc.subjectTurkeysen
dc.titleNetwork antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filamentsen
heal.abstractWe studied the molecular associations between peripherin (a neuronal, type III intermediate filament subunit) and nuclear lamins. We show here that isolated peripherin binds selectively to mammalian lamin B under in vitro conditions. We further demonstrate that a synthetic peptide, representing the proximal part of peripherin's tail domain (P1), also associates with mammalian lamin B in a saturable, cooperative, and specific fashion. Laboratory animals immunized with P1 spontaneously develop idiotypic and anti-idiotypic antibodies recognizing peripherin and lamin B, respectively. These data provide essentially in vivo evidence that lamin B represents a constitutive nuclear "receptor" site for the tail domains of peripherin intermediate filaments.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1986862-
heal.journalNameCellen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1991-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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