Effect of cyclosporin A (CyA) on the immunopathological lesion of the labial minor salivary glands from patients with Sjogren's syndrome
| dc.contributor.author | Dalavanga, Y. A. | en |
| dc.contributor.author | Detrick, B. | en |
| dc.contributor.author | Hooks, J. J. | en |
| dc.contributor.author | Drosos, A. A. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T19:23:00Z | |
| dc.date.available | 2015-11-24T19:23:00Z | |
| dc.identifier.issn | 0003-4967 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22225 | |
| dc.rights | Default Licence | - |
| dc.subject | Cyclosporins/*therapeutic use | en |
| dc.subject | Female | en |
| dc.subject | HLA-DR Antigens/analysis | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Salivary Glands/*drug effects | en |
| dc.subject | Salivary Glands, Minor/*drug effects/immunology/pathology | en |
| dc.subject | Sjogren's Syndrome/*drug therapy/immunology/pathology | en |
| dc.subject | T-Lymphocytes/pathology | en |
| dc.title | Effect of cyclosporin A (CyA) on the immunopathological lesion of the labial minor salivary glands from patients with Sjogren's syndrome | en |
| heal.abstract | Labial minor salivary gland biopsy specimens from 14 patients with Sjogren's syndrome treated either with cyclosporin A (CyA) or placebo (5 mg/kg body weight day for six months) were studied to determine T lymphocyte subsets and HLA-DR antigen expression using the avidin-biotin-peroxidase technique. In all CyA treated patients we observed a decrease in the number of T lymphocytes and in the number of T helper cells, while the percentage of T suppressor cells and B cells was the same in both treated and untreated groups. It was also shown that the HLA-DR antigen expression on the epithelial cells was eliminated in the CyA treated patients. These findings suggest that the HLA-DR antigen expression on the epithelial cells is the result rather than the triggering factor of this T cell mediated process and is probably related to decreased lymphokine production by activated T lymphocytes. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3493738 | - |
| heal.identifier.secondary | http://ard.bmj.com/content/46/2/89.full.pdf | - |
| heal.journalName | Ann Rheum Dis | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1987 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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