The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma

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dc.contributor.authorComoy, E. E.en
dc.contributor.authorPestel, J.en
dc.contributor.authorDuez, C.en
dc.contributor.authorStewart, G. A.en
dc.contributor.authorVendeville, C.en
dc.contributor.authorFournier, C.en
dc.contributor.authorFinkelman, F.en
dc.contributor.authorCapron, A.en
dc.contributor.authorThyphronitis, G.en
dc.date.accessioned2015-11-24T16:31:54Z
dc.date.available2015-11-24T16:31:54Z
dc.identifier.issn0022-1767-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7494
dc.rightsDefault Licence-
dc.subjectcytokine gene-expressionen
dc.subjectlow-affinity receptoren
dc.subjectstimulatory factor-ien
dc.subjectcd4+ lymphocytes-ten
dc.subjectder-p-ien
dc.subjectb-cellen
dc.subjectschistosoma-mansonien
dc.subjecthuman igeen
dc.subjectantibody-responseen
dc.subjectinterferon-gammaen
dc.titleThe house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gammaen
heal.abstractA common property of allergens is their potential to generate type 2 cytokine responses, To understand the mechanisms involved in this phenomenon, we have evaluated the polarizing potential of a major allergen, Dermatophagoides pteronyssinus 1 (Der p 1), in an heterologous immunization system using the glutathione S-transferase of the parasite Schistosoma mansoni (Sm28-GST) as immunogen. In previous studies, we showed that immunization with the Sm28-GST emulsified in CFA induced a nonpolarized immune response, In contrast, when alum was used as adjuvant, a type 2 immune response was induced against Sm28-GST, Using this experimental model, we examined whether the administration of Der p 1 together with Sm28-GST influenced the nonpolarized and/or the Th2 profiles induced by the CFA or the alum immunization, respectively, Our results showed that the introduction of Der p 1 in the CFA immunization protocol was associated with diminished anti-Sm28-GST IgG2a Ab titers, reduced IFN-gamma mRNA expression, and frequency of IFN-gamma-producing cells. In contrast, the introduction of Der p 1 in the alum protocol did not affect IL-4 or Ig isotype responses, The effect of Der p 1 was specific, since coimmunization with tetanus toxin fragment C did not affect the profile of the response against Sm28-GST, Furthermore, inactivation of Der p 1 reduced its ability to modify the immune response profile, suggesting that its protease activity played an important role in deviating the immune response. Our results suggest that the Der p 1 has the ability to modify the profile of an immune response by modulating the balance between the polarizing cytokines IL-4 and IFN-gamma.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000072115700054-
heal.identifier.secondaryhttp://www.jimmunol.org/content/160/5/2456.full.pdf-
heal.journalNameJournal of Immunologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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