Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells

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dc.contributor.authorMoumtzi, S. S.en
dc.contributor.authorRoberts, M. L.en
dc.contributor.authorJoyce, T.en
dc.contributor.authorEvangelidou, M.en
dc.contributor.authorProbert, L.en
dc.contributor.authorFrillingos, S.en
dc.contributor.authorFotsis, T.en
dc.contributor.authorPintzas, A.en
dc.date.accessioned2015-11-24T19:15:02Z
dc.date.available2015-11-24T19:15:02Z
dc.identifier.issn1532-4192-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21442
dc.rightsDefault Licence-
dc.subjectApoptosis/*geneticsen
dc.subjectCell Aging/*geneticsen
dc.subjectCell Cycle/geneticsen
dc.subjectCell Cycle Proteins/genetics/metabolismen
dc.subjectCell Lineen
dc.subjectCell Transformation, Neoplastic/*genetics/metabolism/pathologyen
dc.subjectEnzyme Activationen
dc.subject*Gene Expression Profiling/methodsen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subject*Genes, rasen
dc.subjectHumansen
dc.subjectMitogen-Activated Protein Kinases/genetics/metabolismen
dc.subjectMutationen
dc.subjectOligonucleotide Array Sequence Analysisen
dc.subjectPhosphorylationen
dc.subjectReproducibility of Resultsen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectSignal Transduction/geneticsen
dc.subjectTime Factorsen
dc.subjectTransfectionen
dc.subjectras Proteins/*genetics/metabolismen
dc.titleGene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cellsen
heal.abstractWe developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle genes like c-fos, cyclin E, cdk2, cell-cell contact, and signaling like integrin a6, MEK5, and free radical signaling genes, like proline oxidase. Therefore, Ras-mediated signaling is a fine regulated process both positively and negatively influencing cell cycle, senescence, and apoptosis pathways. Novel early RAS-target genes could be potentially exploited in cancer diagnostics and therapeutics.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.3109/07357900903095623-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19883200-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.3109/07357900903095623-
heal.journalNameCancer Investen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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