P21/waf1 protein expression in nasopharyngeal carcinoma. Comparative study with PCNA, p53 and MDM-2 protein expression

Απλή σελίδα τεκμηρίου
dc.contributor.authorKouvidou, C.en
dc.contributor.authorStefanaki, K.en
dc.contributor.authorDai, Y.en
dc.contributor.authorTzardi, M.en
dc.contributor.authorKoutsoubi, K.en
dc.contributor.authorDarivianaki, K.en
dc.contributor.authorKaridi, E.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorZois, E.en
dc.contributor.authorKakolyris, S.en
dc.contributor.authorGeorgoulias, V.en
dc.contributor.authorDelides, G.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:00:20Z
dc.date.available2015-11-24T19:00:20Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19511
dc.rightsDefault Licence-
dc.subjectCarcinoma/*metabolismen
dc.subjectCyclin-Dependent Kinase Inhibitor p21en
dc.subjectCyclins/*metabolismen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectNasopharyngeal Neoplasms/*metabolismen
dc.subjectNeoplasm Proteins/metabolismen
dc.subject*Nuclear Proteinsen
dc.subjectProliferating Cell Nuclear Antigen/metabolismen
dc.subjectProto-Oncogene Proteins/metabolismen
dc.subjectProto-Oncogene Proteins c-mdm2en
dc.subjectTumor Suppressor Protein p53/metabolismen
dc.titleP21/waf1 protein expression in nasopharyngeal carcinoma. Comparative study with PCNA, p53 and MDM-2 protein expressionen
heal.abstractWe investigated the immunohistochemical expression of p21/waf1 protein in 59 cases of nasopharyngeal carcinomas (NPC) and compared p21 expression with PCNA, p53 and mdm2 protein expression. We found p21, PCNA, p53 and mdm2 in 59/59, 59/59, 18/59 and 12/59 nasopharyngeal carcinomas, respectively. We observed a tendency to a relationship between high expression of PCNA (> 25% positivity in tumour cells) and low expression of p21 protein. Parallel p53/p21 protein expression was found in 18 cases. Twelve were also mdm2 positive. This pattern may represent NPC with wild type (wt) p53 since mdm2 and p21 proteins are inducible by wt p53 gene. In these cases p53 protein expression may be due to stabilisation to mdm2 protein. This could be important in the pathogenesis of these cases since mdm2 may deregulate the p53-dependent growth suppressive pathway. Discordant p53-/p21+ protein expression was found in 41 cases. All were also mdm2 negative. This pattern suggests immunohistochemically undetectable wt p53 gene which is able to induce p21 protein expression.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9252690-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1997-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ