Individual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brain

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dc.contributor.authorPolissidis, A.en
dc.contributor.authorChouliara, O.en
dc.contributor.authorGalanopoulos, A.en
dc.contributor.authorRentesi, G.en
dc.contributor.authorDosi, M.en
dc.contributor.authorHyphantis, T.en
dc.contributor.authorMarselos, M.en
dc.contributor.authorPapadopoulou-Daifoti, Z.en
dc.contributor.authorNomikos, G. G.en
dc.contributor.authorSpyraki, C.en
dc.contributor.authorTzavara, E. T.en
dc.contributor.authorAntoniou, K.en
dc.date.accessioned2015-11-24T19:10:31Z
dc.date.available2015-11-24T19:10:31Z
dc.identifier.issn1469-5111-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20836
dc.rightsDefault Licence-
dc.subjectAnalgesics/administration & dosage/pharmacologyen
dc.subjectAnimalsen
dc.subjectBehavior, Animal/*drug effectsen
dc.subjectBenzoxazines/administration & dosage/pharmacologyen
dc.subjectBrain/*drug effects/metabolismen
dc.subjectCannabinoids/*pharmacologyen
dc.subjectCorpus Striatum/drug effects/metabolismen
dc.subjectDopamine/*metabolismen
dc.subjectDopamine and cAMP-Regulated Phosphoprotein 32/*metabolismen
dc.subjectDose-Response Relationship, Drugen
dc.subjectMaleen
dc.subjectMorpholines/administration & dosage/pharmacologyen
dc.subjectMotor Activity/*drug effectsen
dc.subjectNaphthalenes/administration & dosage/pharmacologyen
dc.subjectNucleus Accumbens/drug effects/metabolismen
dc.subjectPhosphorylation/drug effectsen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectTetrahydrocannabinol/*pharmacologyen
dc.titleIndividual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brainen
heal.abstractThis study explored the behavioural, neurochemical and molecular effects of Delta9-tetrahydrocannabinol (Delta9-THC) and WIN55,212-2, in two rat phenotypes, distinguished on the basis of their vertical activity upon exposure to a novel environment, as high responders (HR) and low responders (LR). Motor effects were assessed under habituated vs. non-habituated conditions. Dopaminergic activity and DARPP-32 phosphorylation were measured in the dorsal striatum, nucleus accumbens, prefrontal cortex and amygdala. These cannabinoids influenced motor activity in a biphasic manner, i.e. low doses stimulated, whereas high doses suppressed motor activity. Dopamine (DA) biosynthesis was increased in most brain regions studied following Delta9-THC administration mainly in HR rats, and low-dose WIN55,212-2 increased DA biosynthesis in HR rats only. Both high and low doses of Delta9-THC increased DARPP-32 phosphorylation in most brain regions studied in both phenotypes, an effect that was also observed following high-dose WIN55,212-2 administration only in the striatum. The present results provide further support for a key role of cannabinoids in the regulation of motoric responses and elements of dopaminergic neurotransmission and reveal their complex differential effects in distinct rat phenotypes, as seen with other drugs of abuse.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1017/S1461145709991003-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19941698-
heal.identifier.secondaryhttp://journals.cambridge.org/download.php?file=%2FPNP%2FPNP13_09%2FS1461145709991003a.pdf&code=62158716424804d108c095f29250a990-
heal.journalNameInt J Neuropsychopharmacolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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