Growth hormone response to thyrotrophin releasing hormone in women with polycystic ovarian syndrome
| dc.contributor.author | Kaltsas, T. | en |
| dc.contributor.author | Pontikides, N. | en |
| dc.contributor.author | Krassas, G. E. | en |
| dc.contributor.author | Seferiadis, K. | en |
| dc.contributor.author | Lolis, D. | en |
| dc.contributor.author | Messinis, I. E. | en |
| dc.date.accessioned | 2015-11-24T19:14:29Z | |
| dc.date.available | 2015-11-24T19:14:29Z | |
| dc.identifier.issn | 0268-1161 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21320 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Androstenedione/blood | en |
| dc.subject | Blood Glucose/metabolism | en |
| dc.subject | Body Mass Index | en |
| dc.subject | Estradiol/blood | en |
| dc.subject | Fatty Acids, Nonesterified/blood | en |
| dc.subject | Female | en |
| dc.subject | Human Growth Hormone/blood/*secretion | en |
| dc.subject | Humans | en |
| dc.subject | Insulin/blood | en |
| dc.subject | Insulin-Like Growth Factor I/metabolism | en |
| dc.subject | Kinetics | en |
| dc.subject | Polycystic Ovary Syndrome/*physiopathology | en |
| dc.subject | Testosterone/blood | en |
| dc.subject | Thyrotropin-Releasing Hormone/administration & dosage/*diagnostic use | en |
| dc.title | Growth hormone response to thyrotrophin releasing hormone in women with polycystic ovarian syndrome | en |
| heal.abstract | Recent clinical studies have suggested that women with polycystic ovarian syndrome (PCOS) may have disturbances of growth hormone (GH) kinetics and the GH/insulin-like growth factor (IGF)-I system. The knowledge that in various metabolic abnormalities there is a paradoxical sensitivity of pituitary somatotrophs to thyrotrophin releasing hormone (TRH) administration led to this investigation of the GH secretory response to TRH in women with PCOS. Twenty-four women with PCOS and 18 control women were studied. TRH was given as a single i.v. injection (time 0) and blood samples for GH measurements were obtained at -15, 0, 15, 30, 60 and 90 min. The GH responses were expressed as the area under the curve (AUC) or the differences from the basal value (Deltamax). The GH response to TRH (mean +/- SEM) was greater in women with PCOS (Deltamax 2.47 +/- 1. 73 versus 0.47 +/- 0.06 ng/ml, P < 0.05 and GH AUC 8.05 +/- 2.10 versus 2.58 +/- 0.18 ng/ml/90 min, P < 0.05). According to GH response to TRH, two PCOS subgroups were identified: (i) normal responders (n = 14) who showed Deltamax GH response (0.36 +/- 0.06 ng/ml)and GH AUC (1.93 +/- 0.64 ng/ml/90 min) similar to that in the controls and (ii) over-responders (n +/- 10) who showed a paradoxical increase in GH concentrations in response to TRH (Deltamax GH response 5.43 +/- 1.27 ng/ml and GH AUC 16.62 +/- 3.51 ng/ml per 90 min) that was significantly higher than in normally responding PCOS patients (P < 0.0001) or in controls (P < 0.0001). These data demonstrate an enhanced GH response to TRH administration in a subgroup of women with PCOS. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10548605 | - |
| heal.identifier.secondary | http://humrep.oxfordjournals.org/content/14/11/2704.full.pdf | - |
| heal.journalName | Hum Reprod | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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