CD44s expression, in benign, borderline and malignant tumors of ovarian surface epithelium. Correlation with p53, steroid receptor status, proliferative indices (PCNA, MIB1) and survival

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dc.contributor.authorZagorianakou, N.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorMakrydimas, G.en
dc.contributor.authorZagorianakou, P.en
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorKaravasilis, B.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:31:24Z
dc.date.available2015-11-24T19:31:24Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23258
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntigens, CD44/*biosynthesisen
dc.subjectCell Division/physiologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKi-67 Antigen/biosynthesisen
dc.subjectMiddle Ageden
dc.subjectOvarian Neoplasms/*metabolism/*pathologyen
dc.subjectProliferating Cell Nuclear Antigen/biosynthesisen
dc.subjectReceptors, Estrogen/*biosynthesisen
dc.subjectReceptors, Progesterone/*biosynthesisen
dc.subjectSurvival Rateen
dc.subjectTumor Suppressor Protein p53/*biosynthesisen
dc.titleCD44s expression, in benign, borderline and malignant tumors of ovarian surface epithelium. Correlation with p53, steroid receptor status, proliferative indices (PCNA, MIB1) and survivalen
heal.abstractAIM: To investigate the role of CD44s in the biological behavior of surface epithelial ovarian tumors and its correlation with clinicopathological parameters, prognosis, p53, steroid receptor status and proliferative indices (PCNA, MIB1). MATERIALS AND METHODS: We analyzed a total of 83 patients with ovarian surface epithelial tumors, for the immunohistochemical expression of CD44s and the possible correlation with clinicopathological factors and patients' outcome. RESULTS: A statistically significant correlation was found between the expression of CD44s, which was higher in cancer cases than in benign cystadenomas (p<0.0001) and, between cancer cases, which was lower in borderline tumors, (p=0.05). No statistical correlation was found between CD44s expression and the examined markers. In overall survival analysis we did not detect a statistically significant correlation with the expression of CD44s. CONCLUSION: The current study demonstrates that CD44s may be functionally involved in the pathogenesis of epithelial ovarian lesions.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15274338-
heal.journalNameAnticancer Researchen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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