Long-term effects of low molecular weight heparin on lipid parameters in hemodialysis patients
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Bairaktari, H. | en |
| dc.contributor.author | Germanos, N. | en |
| dc.contributor.author | Pappas, M. | en |
| dc.contributor.author | Koulouridis, E. | en |
| dc.contributor.author | Papagalanis, N. | en |
| dc.contributor.author | Siamopoulos, K. C. | en |
| dc.date.accessioned | 2015-11-24T19:06:28Z | |
| dc.date.available | 2015-11-24T19:06:28Z | |
| dc.identifier.issn | 0392-9590 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20342 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Anticoagulants/*administration & dosage | en |
| dc.subject | Apolipoproteins B/blood | en |
| dc.subject | Child | en |
| dc.subject | Cholesterol, HDL/blood | en |
| dc.subject | Female | en |
| dc.subject | Heparin, Low-Molecular-Weight/*administration & dosage | en |
| dc.subject | Humans | en |
| dc.subject | Lipids/*blood | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Prospective Studies | en |
| dc.subject | *Renal Dialysis | en |
| dc.subject | Triglycerides/blood | en |
| dc.title | Long-term effects of low molecular weight heparin on lipid parameters in hemodialysis patients | en |
| heal.abstract | OBJECTIVE: The long-term effects of the replacement of conventional heparin by low-molecular weight heparin (LMWH) on lipid parameters were examined in a large group of hemodialysis patients. EXPERIMENTAL DESIGN: One-year prospective investigation. SETTING: Renal units. PATIENTS: A total of 93 patients aged 12-63 years old receiving hemodialysis for 51 (1-172) months were studied. None of the patients had primary hyperlipidemia, diabetes mellitus, or other secondary causes of dyslipidemia. INTERVENTIONS: In all patients administration of LMWH was introduced in doses 2500-5000 units. MEASURES: Baseline values of lipoprotein profile prior to the intervention were compared with results obtained after 3, 6 and 12 months of LMWH. RESULTS: During of LMWH treatment a small but statistically significant decrease of total and HDL cholesterol (from 200 +/- 45 mg/dl to 185 +/- 42 mg/dl, p < 0.01, and from 45 +/- 11 mg/dl to 42 +/- 10 mg/dl, p < 0.05, respectively), as well as Apo B (from 128 +/- 36 mg/dl to 121 +/- 35 mg/dl, p < 0.001) was noticed. Moreover, triglycerides decreased significantly (from 175 +/- 73 mg/dl to 146 +/- 62 mg/dl, p < 0.001). The beneficial effects of LMWH were more pronounced in patients with dyslipidemia (total cholesterol > 200 mg/dl, or triglycerides > 200 mg/dl) before the replacement of conventional heparin. CONCLUSION: The long-term use of LMWH instead of conventional heparin for anticoagulation during dialysis has beneficial effects on the lipoprotein profile, especially in patients with dyslipidemia. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8971586 | - |
| heal.journalName | Int Angiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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