Structure and function of the myelin proteins: Current status and perspectives in relation to multiple sclerosis

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dc.contributor.authorTzakos, A. G.en
dc.contributor.authorKursula, P.en
dc.contributor.authorTroganis, A.en
dc.contributor.authorTheodorou, V.en
dc.contributor.authorTselios, T.en
dc.contributor.authorSvarnas, C.en
dc.contributor.authorMatsoukas, J.en
dc.contributor.authorApostolopoulos, V.en
dc.contributor.authorGerothanassis, I. P.en
dc.date.accessioned2015-11-24T16:48:15Z
dc.date.available2015-11-24T16:48:15Z
dc.identifier.issn0929-8673-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9296
dc.rightsDefault Licence-
dc.subjectmultiple sclerosisen
dc.subjectproteins of the myelin sheathen
dc.subjectmbpen
dc.subjectmhcen
dc.subjecttcren
dc.subjectdockingen
dc.subjectepitopesen
dc.subjectstructureen
dc.subjectmarie-tooth diseaseen
dc.subjectcentral-nervous-systemen
dc.subjectexperimental allergic encephalomyelitisen
dc.subject2',3'-cyclic nucleotide 3'-phosphodiesteraseen
dc.subjectmajor histocompatibility complexen
dc.subjectoligodendrocytic basic-proteinen
dc.subjectclass-ii moleculeen
dc.subjectcalcium-binding proteinsen
dc.subjectamino-acid-sequencesen
dc.subjectperipheral myelinen
dc.titleStructure and function of the myelin proteins: Current status and perspectives in relation to multiple sclerosisen
heal.abstractMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and loss of neurological function, local macrophage infiltrate and neuroantigen-specific CD4(+)T cells. MS arises from complex interactions between genetic, immunological, infective and biochemical mechanisms. Although the circumstances of MS etiology remain hypothetical, one persistent theme involves immune system recognition of myelin-specific antigens derived from myelin basic protein, the most abundant extrinsic myelin membrane protein, and/or another equally suitable myelin protein or lipid. Knowledge of the biochemical and physico-chemical properties of myelin proteins and lipids, particularly their composition, organization, structure and accessibility with respect to the compacted myelin multilayers, becomes central to understanding how and why myelin-specific antigens become selected during the development of MS. This review focuses on the current understanding of the molecular basis of MS with emphasis: (i) on the physical-chemical properties, organization, morphology, and accessibility of the proteins and lipids within the myelin multilayers; (ii) on the structure-function relationships and characterization of the myelin proteins relevant to the manifestation and evolution of MS; (iii) on conformational relationships between myelin epitopes which might become selected during the development of MS; (iv) on the structure of MHC/HLA in complex with MBP peptides as well as with TCR, which is crucial to the understanding of the pathogenesis of MS with the ultimate goal of designed antigen-specific treatments.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.2174/0929867054039026-
heal.identifier.secondary<Go to ISI>://000229295700010-
heal.journalNameCurr Med Chemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.publisherBentham Science Publishersen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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