Male aromatase-knockout mice exhibit normal levels of activity, anxiety and "depressive-like" symptomatology
Φόρτωση...
Ημερομηνία
Συγγραφείς
Dalla, C.
Antoniou, K.
Papadopoulou-Daifoti, Z.
Balthazart, J.
Bakker, J. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Behav Brain Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
It is well known that estradiol derived from neural aromatization of testosterone plays a crucial role in the development of the male brain and the display of sexual behaviors in adulthood. It was recently found that male aromatase knockout mice (ArKO) deficient in estradiol due to a mutation in the aromatase gene have general deficits in coital behavior and are sexually less motivated. We wondered whether these behavioral deficits of ArKO males could be related to changes in activity, exploration, anxiety and "depressive-like" symptomatology. ArKO and wild type (WT) males were subjected to open field (OF), elevated plus maze (EPM), and forced swim tests (FST), after being exposed or not to chronic mild stress (CMS). CMS was used to evaluate the impact of chronic stressful procedures and to unveil possible differences between genotypes. There was no effect of genotype on OF, EPM and FST behavioral parameters. WT and ArKO mice exposed to CMS or not exhibited the same behavioral profile during these three types of tests. However, all CMS-exposed mice (ArKO and WT) spent less time in the center of the EPM. Additionally, floating duration measured in the FST increased between two tests in both WT and ArKO mice, though that increase was less prominent in mice previously subjected to CMS than in controls. Therefore, both ArKO and WT males displayed the same behavior and had the same response to CMS however CMS exposure slightly modified the behavior displayed by mice of both genotypes in the FST and EPM paradigms. These results show that ArKO males display normal levels of activity, exploration, anxiety and "depressive-like" symptomatology and thus their deficits in sexual behavior are specific in nature and do not result indirectly from other behavioral changes.
Περιγραφή
Λέξεις-κλειδιά
Analysis of Variance, Animals, Anxiety/*genetics/physiopathology, Aromatase/*deficiency, Behavior, Animal, Depression/*genetics/physiopathology, Exploratory Behavior/physiology, Male, Maze Learning/physiology, Mice, Mice, Knockout/*physiology, Motor Activity/*genetics, Stress, Physiological/physiopathology, Swimming/physiology, Time Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16029903
http://ac.els-cdn.com/S0166432805002287/1-s2.0-S0166432805002287-main.pdf?_tid=65d22b8c950f974f740681972d3b80dd&acdnat=1332924949_fcedd8d233002b73f41f2fdf9a7b5f91
http://ac.els-cdn.com/S0166432805002287/1-s2.0-S0166432805002287-main.pdf?_tid=65d22b8c950f974f740681972d3b80dd&acdnat=1332924949_fcedd8d233002b73f41f2fdf9a7b5f91
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής