Prevention of peritoneal adhesions in rats with verapamil, hydrocortisone sodium succinate, and phosphatidylcholine
| dc.contributor.author | Kappas, A. M. | en |
| dc.contributor.author | Barsoum, G. H. | en |
| dc.contributor.author | Ortiz, J. B. | en |
| dc.contributor.author | Keighley, M. R. | en |
| dc.date.accessioned | 2015-11-24T18:56:40Z | |
| dc.date.available | 2015-11-24T18:56:40Z | |
| dc.identifier.issn | 1102-4151 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19076 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Female | en |
| dc.subject | Hydrocortisone/*analogs & derivatives/therapeutic use | en |
| dc.subject | Peritoneal Diseases/*prevention & control | en |
| dc.subject | Peritoneal Lavage | en |
| dc.subject | Phosphatidylcholines/*therapeutic use | en |
| dc.subject | Postoperative Complications/*prevention & control | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Strains | en |
| dc.subject | Sodium Chloride | en |
| dc.subject | Tissue Adhesions/prevention & control | en |
| dc.subject | Verapamil/*therapeutic use | en |
| dc.title | Prevention of peritoneal adhesions in rats with verapamil, hydrocortisone sodium succinate, and phosphatidylcholine | en |
| heal.abstract | OBJECTIVE: To assess the effectiveness of verapamil, hydrocortisone sodium succinate, and phosphatidylcholine in the prevention of experimental adhesions. DESIGN: Randomized trial. MATERIAL: 80 rats. INTERVENTIONS: Laparotomy and intraperitoneal irrigation with saline 40 degrees C, then verapamil hydrochloride 1 mg/kg intravenously 15 min before, during, and after irrigation; or hydrocortisone sodium succinate 50 mg/kg intravenously half an hour before irrigation; or phosphatidylcholine 5.5 mg/kg orally eight days before and seven days after irrigation plus 0.5 mg/ml in the irrigation fluid; or no further intervention. MAIN OUTCOME MEASURES: Development of adhesions two weeks after irrigation, and completeness of wound healing. RESULTS: Adhesions developed in 13 of 19 control animals; 7 of 20 that were given verapamil; 6 of 20 that were given hydrocortisone; and 3 of 20 given phosphatidylcholine. CONCLUSION: Adhesions that developed in rats after laparotomy and intraperitoneal irrigation with saline at 40 degrees C can be significantly reduced by phosphatidylcholine. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/1348638 | - |
| heal.journalName | Eur J Surg | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1992 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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