Pituitary size fluctuation in long-term MR studies of PROP1 deficient patients: A persistent pathophysiological mechanism?

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dc.contributor.authorVoutetakis, A.en
dc.contributor.authorSertedaki, A.en
dc.contributor.authorLivadas, S.en
dc.contributor.authorXekouki, P.en
dc.contributor.authorBossis, I.en
dc.contributor.authorDacou-Voutetakis, C.en
dc.contributor.authorArgyropoulou, M. I.en
dc.date.accessioned2015-11-24T18:58:21Z
dc.date.available2015-11-24T18:58:21Z
dc.identifier.issn0391-4097-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19269
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectHomeodomain Proteins/*geneticsen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectOrgan Sizeen
dc.subjectPituitary Diseases/genetics/pathology/*physiopathologyen
dc.subjectPituitary Gland/*pathologyen
dc.subjectPituitary Hormones/*deficiencyen
dc.titlePituitary size fluctuation in long-term MR studies of PROP1 deficient patients: A persistent pathophysiological mechanism?en
heal.abstractInactivating PROP1 gene alterations are responsible for over 50% of familial combined pituitary hormone deficiency cases. Pituitary enlargement followed by regression and subnormal pituitary size has been documented in a number of PROP1 deficient patients. Data derived from PROP1 deficient mice (Ames dwarfs) have revealed some of the underlying cellular mechanisms. Nevertheless, long-term magnetic resonance imaging (MRI) findings in two PROP1 deficient patients suggest the evolution of pituitary pathology as more complex and persistent than previously described. Patient A had enlarged pituitary gland (pituitary height: 9-10 mm), demonstrated by serial MRI carried out from age 5 to 8.5 yr, small pituitary gland (4 mm) at age 10 yr and pituitary enlargement (11 mm) at age 19 yr. Patient B had a pituitary gland of normal size at age 7 yr (5 mm), whereas at age 14.3 and 16.3 yr, an enlarged pituitary gland was disclosed (10 and 11 mm, respectively). Both series of events are suggestive of a persistent pathophysiological mechanism in the pituitary gland of patients with PROP1 gene defects. Therefore, long-term pituitary follow-up by MRI in such patients may be necessary even in the case of a small or normal pituitary gland. It must be noted that current data from the Ames dwarf mouse cannot fully explain the observed pituitary size fluctuation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16794371-
heal.journalNameJournal of Endocrinological Investigationen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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