Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kolettis, T. M.
Baltogiannis, G. G.
Tsalikakis, D. G.
Tzallas, A. T.
Agelaki, M. G.
Fotopoulos, A.
Fotiadis, D. I.
Kyriakides, Z. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
European Journal of Pharmacology
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The effects of dual (ETA and ETB) endothelin receptor blockade on ventricular arrhythmogenesis during acute myocardial infarction are not well defined. We randomly allocated Wistar rats to bosentan (100 mg/kg daily, n=24), a dual endothelin receptor antagonist, or vehicle (n=23). After 7 days of treatment, myocardial infarction was induced by permanent coronary ligation. Ventricular tachyarrhythmias were evaluated for 24 h following ligation, using a miniature telemetry electrocardiogram recorder. Action potential duration was measured from monophasic epicardial recordings and sympathetic activation was assessed by heart rate variability and catecholamine serum level measurements. Compared to controls (1012+/-185 s), bosentan (59+/-24 s) markedly decreased (P<0.00001) the total duration of ventricular tachyarrhythmias during the delayed (1-24 h) phase post-ligation, with a modest effect during the early (0-1 h) phase (132+/-38 s, versus 43+/-18 s, respectively, P=0.053). Treatment did not affect infarct size or total mortality. Action potential duration at 90% repolarization prolonged in controls (from 93.1+/-4.7 ms to 117.6+/-6.9 ms), displaying increased temporal dispersion (from 4.14+/-0.45 ms to 10.42+/-2.51 ms, both P<0.001), but was preserved in treated animals. Bosentan decreased norepinephrine, but increased epinephrine levels 24 h post-ligation. Low frequency spectra of heart rate variability, an index of net sympathetic tone, were lower in bosentan-treated rats. Dual endothelin-1 receptor blockade decreases ventricular tachyarrhythmias during myocardial infarction without reperfusion, by preventing repolarization inhomogeneity. Diverse treatment effects on sympathetic activation may ameliorate the antiarrhythmic action.
Περιγραφή
Λέξεις-κλειδιά
Action Potentials/drug effects, Animals, Antihypertensive Agents/*pharmacology, Electrocardiography, Epinephrine/metabolism, Myocardial Infarction/complications/*drug therapy, Norepinephrine/metabolism, Random Allocation, Rats, Rats, Wistar, Receptor, Endothelin A/*antagonists & inhibitors, Receptor, Endothelin B/*antagonists & inhibitors, Sulfonamides/*pharmacology, Sympathetic Nervous System/drug effects/metabolism, Tachycardia, Ventricular/*drug therapy/etiology, Telemetry, Ventricular Fibrillation/drug therapy/etiology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18048027
http://ac.els-cdn.com/S001429990701240X/1-s2.0-S001429990701240X-main.pdf?_tid=4c519ae22d585db545eee9c74b2ce7fe&acdnat=1333699152_3c7f86d4c556abc8e5a855a7a7eb045f
http://ac.els-cdn.com/S001429990701240X/1-s2.0-S001429990701240X-main.pdf?_tid=4c519ae22d585db545eee9c74b2ce7fe&acdnat=1333699152_3c7f86d4c556abc8e5a855a7a7eb045f
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής