Metsovo lung: pleural calcification and restrictive lung function in northwestern Greece. Environmental exposure to mineral fiber as etiology
Φόρτωση...
Ημερομηνία
Συγγραφείς
Constantopoulos, S. H.
Goudevenos, J. A.
Saratzis, N.
Langer, A. M.
Selikoff, I. J.
Moutsopoulos, H. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Environ Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Pleural calcifications are described in 122 of 268 (45.5%) inhabitants of four villages (Metsovo, Anilio, Milea, and Votonosi) in a small area of northwestern Greece (total population about 5000). All affected individuals are of one ethnic group, Vlachi. Calcifications were not noted in any of the 103 persons in the control group made up of 73 non-Vlachi inhabitants from the same and neighboring villages and 30 Vlachi from distant villages. The calcifications were seen in both sexes, equally, and their frequently increased with age, from 28.6% between 30 and 39 years to 81.0% in individuals over 70 years of age. When plaque development was extensive, a small restrictive pulmonary function defect was noted. Because of its prevalence in the Metsovo area we call this clinical pattern Metsovo lung. The identification of tremolite, related amphibole fibers, and traces of chrysotile fiber in settled dusts and soil specimens and of identical fibers in tissue specimens obtained at lung biopsy from 8 people with plaques supports the hypothesis that abestiform minerals are the agents responsible for these disease processes. Further, reports of the occurrence of mesothelioma and benign pleural effusions in inhabitants in the Metsovo area, along with the striking similarities to disease patterns observed in the Karain area of Turkey, add further weight to the hypothesis that mineral fiber(s) in the environment of the four villages are agent(s) in the etiology of Metsovo lung.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Body Burden, Calcinosis/*etiology, Environmental Exposure, Female, Greece, Humans, Lung/radiography, Lung Diseases/*etiology, Male, Middle Aged, Minerals/*adverse effects, Pleural Diseases/*etiology, Spirometry
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/4065080
http://ac.els-cdn.com/0013935185900969/1-s2.0-0013935185900969-main.pdf?_tid=594fbec58262f6b7f9d8439979288cce&acdnat=1333519099_7249e9d0b45af8191fd149b3f648e61e
http://ac.els-cdn.com/0013935185900969/1-s2.0-0013935185900969-main.pdf?_tid=594fbec58262f6b7f9d8439979288cce&acdnat=1333519099_7249e9d0b45af8191fd149b3f648e61e
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής