The adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and proinflammatory markers

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dc.contributor.authorXita, N.en
dc.contributor.authorPapassotiriou, I.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorVounatsou, M.en
dc.contributor.authorMargeli, A.en
dc.contributor.authorTsatsoulis, A.en
dc.date.accessioned2015-11-24T19:42:34Z
dc.date.available2015-11-24T19:42:34Z
dc.identifier.issn0026-0495-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24659
dc.rightsDefault Licence-
dc.subjectAdiponectin/*blooden
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectC-Reactive Protein/*analysisen
dc.subjectCholesterol, HDL/blooden
dc.subjectFemaleen
dc.subjectHumansen
dc.subject*Insulin Resistanceen
dc.subjectLeptin/*blooden
dc.subjectPolycystic Ovary Syndrome/*blooden
dc.titleThe adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and proinflammatory markersen
heal.abstractCentral adiposity plays an important role in the insulin resistance of the polycystic ovary syndrome (PCOS) through the dysregulated production of various adipokines. Polycystic ovary syndrome has also been described as a low-grade inflammation state characterized by elevated levels of C-reactive protein (CRP). Furthermore, CRP is a strong independent predictor of the metabolic syndrome and cardiovascular disease. Recently, the adiponectin-to-leptin (A/L) ratio has been proposed as a potential atherogenic index in obese type 2 diabetic patients. The aim of this study was to evaluate the potential role of the A/L ratio in the metabolic and proinflammatory phenotype of PCOS. We studied 74 Greek women with PCOS (38 normal-weight and 36 overweight-obese women). The A/L ratio was negatively correlated with BMI (r = -0.79 P < .001), homeostasis model assessment (r = -0.642, P < .001), triglycerides (r = -0.67, P < .001), and total cholesterol (r = -0.38, P < .01), and positively correlated with high-density lipoprotein cholesterol (r = 0.38, P < .01) and sex hormone-binding globulin (r = 0.39, P = .001). After controlling for BMI, the A/L ratio was independently associated with insulin resistance indexes and triglycerides. Furthermore, the A/L ratio was negatively correlated with CRP (r = -0.746, P < .0001). Multiple regression analysis revealed that BMI and the A/L ratio were the only independent significant determinants of CRP (beta = .436, P = .003 and beta = -.398, P = .007, respectively). Studying normal-weight and overweight-obese women separately, we found an independent association between the A/L ratio and CRP in both groups (beta = -.460, P = .009 in normal-weight women and beta = -.570, P = .001 in overweight-obese women). In conclusion, the A/L ratio may serve as a biomarker of both insulin resistance and low-grade inflammation, providing the link between these cardiovascular risk factors in women with PCOS.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.metabol.2007.01.008-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17512308-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0026049507000601/1-s2.0-S0026049507000601-main.pdf?_tid=e571e2853c6c44d4c21021734c7817d5&acdnat=1333347643_357d40c5c5ca090e029b7d910240c911-
heal.journalNameMetabolismen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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