A case study of multiple-treatments meta-analysis demonstrates that covariates should be considered
Φόρτωση...
Ημερομηνία
Συγγραφείς
Salanti, G.
Marinho, V.
Higgins, J. P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Clin Epidemiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To illustrate the potential and challenges of the simultaneous analysis of a network of trials, using as a case study the investigation of the relative effectiveness of four topical fluoride treatments and two control interventions (placebo and no treatment) in preventing dental caries in children. STUDY DESIGN AND SETTING: We performed multiple-treatments meta-analysis within a Bayesian framework by synthesizing six Cochrane reviews. We explored the compatibility between direct and indirect evidence and adjusted the results using a meta-regression model to take into account differences in the year of randomization across studies. RESULTS: The validity of our conclusions for the superiority of fluoride toothpaste as indicated from the initial network analysis using Bayesian methods was challenged when we adjusted for possible confounders. The network was dominated by studies comparing placebo with toothpaste, which were older and had been carried out in populations with higher baseline risk than studies involving other fluoride modalities. CONCLUSION: After adjusting for possible differences across studies, we did not find clear evidence that any topical fluoride modality is more effective than any other. Multiple-treatments meta-analysis methods allow for more detailed investigations than naive methods in the analysis of indirect evidence on treatment effects.
Περιγραφή
Λέξεις-κλειδιά
Administration, Topical, Cariostatic Agents/*administration & dosage, Confounding Factors (Epidemiology), Dental Caries/*prevention & control, Evidence-Based Medicine/methods, Fluorides/*administration & dosage, Humans, *Meta-Analysis as Topic, Mouthwashes, Randomized Controlled Trials as Topic, Review Literature as Topic, Toothpastes, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19157778
http://ac.els-cdn.com/S089543560800276X/1-s2.0-S089543560800276X-main.pdf?_tid=4d177654a354da650f2b11658515df69&acdnat=1333018209_fe6cd7e1318de38a1254583e0029cd29
http://ac.els-cdn.com/S089543560800276X/1-s2.0-S089543560800276X-main.pdf?_tid=4d177654a354da650f2b11658515df69&acdnat=1333018209_fe6cd7e1318de38a1254583e0029cd29
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής