Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour

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dc.contributor.authorDriessens, G.en
dc.contributor.authorHarsan, L.en
dc.contributor.authorRobaye, B.en
dc.contributor.authorWaroquier, D.en
dc.contributor.authorBrowaeys, P.en
dc.contributor.authorGiannakopoulos, X.en
dc.contributor.authorVelu, T.en
dc.contributor.authorBruyns, C.en
dc.date.accessioned2015-11-24T19:04:25Z
dc.date.available2015-11-24T19:04:25Z
dc.identifier.issn0007-0920-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20037
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAnnexin A5/metabolismen
dc.subjectAntineoplastic Agents/therapeutic useen
dc.subjectApoptosis/drug effectsen
dc.subjectBrain Neoplasms/drug therapy/*genetics/radiotherapyen
dc.subjectCaspase 3en
dc.subjectCaspases/metabolismen
dc.subjectCisplatin/therapeutic useen
dc.subjectDNA Damage/drug effectsen
dc.subjectDNA, Neoplasm/drug effectsen
dc.subjectGlioma/drug therapy/*genetics/radiotherapyen
dc.subjectIn Situ Nick-End Labelingen
dc.subjectMicronuclei, Chromosome-Defective/*geneticsen
dc.subjectMicronucleus Testsen
dc.subjectRatsen
dc.subjectRats, Inbred F344en
dc.subjectTumor Cells, Cultureden
dc.subjectTumor Suppressor Protein p53/*geneticsen
dc.titleMicronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumouren
heal.abstractApoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage induced by chemotherapy in a p53-mutated solid tumour.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1038/sj.bjc.6601163-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12915886-
heal.identifier.secondaryhttp://www.nature.com/bjc/journal/v89/n4/pdf/6601163a.pdf-
heal.journalNameBr J Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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