Fas and WAF1 expression in esophageal squamous cell carcinomas

dc.contributor.authorVlachos, K.en
dc.contributor.authorSiafakas, N.en
dc.contributor.authorKarameris, A.en
dc.contributor.authorAthanasas, G.en
dc.contributor.authorTheodoropoulos, G.en
dc.contributor.authorParassi, E.en
dc.contributor.authorPeros, G.en
dc.contributor.authorPapadopoulos, J.en
dc.contributor.authorHakim, N.en
dc.date.accessioned2015-11-24T19:16:10Z
dc.date.available2015-11-24T19:16:10Z
dc.identifier.issn0020-8868-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21623
dc.rightsDefault Licence-
dc.subjectAntigens, CD95/*biosynthesisen
dc.subjectCarcinoma, Squamous Cell/*metabolism/*pathology/surgeryen
dc.subjectCyclin-Dependent Kinase Inhibitor p21/*biosynthesisen
dc.subjectEsophageal Neoplasms/*metabolism/*pathology/surgeryen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.titleFas and WAF1 expression in esophageal squamous cell carcinomasen
heal.abstractThe Fas/FasL system plays an important role in the regulation of tumor apoptosis. This study examined the correlation between the expression levels of Fas and WAF1 with the clinicopathological characteristics of esophageal squamous cell carcinoma (SCC) tumors. Paraffin-embedded sections from 19 surgically resected primary esophageal squamous cell carcinomas were examined by immunohistochemistry. At low expression levels (5% to 24%), a 4-fold higher expression of Fas relative to WAF1 expression was observed. High expression levels (50% to 74%) of Fas were not recorded, whereas such levels of expression for WAF1 were retained in a proportion of cells > 20%. Proteins WAF1 and Fas were both expressed in all lesions of SCCs. Lesions showing high expression levels of WAF1 have a high degree of differentiation, but a sample that expresses WAF1 and belongs to the morphology I category probably has a medium degree of differentiation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17256429-
heal.journalNameInt Surgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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