Advanced stage clear-cell epithelial ovarian cancer: the Hellenic Cooperative Oncology Group experience
Φόρτωση...
Ημερομηνία
Συγγραφείς
Pectasides, D.
Fountzilas, G.
Aravantinos, G.
Kalofonos, C.
Efstathiou, H.
Farmakis, D.
Skarlos, D.
Pavlidis, N.
Economopoulos, T.
Dimopoulos, M. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Gynecol Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: Ovarian clear-cell carcinomas (OCCC) are known to be possibly resistant to platinum-based chemotherapy and to have a poorer prognosis with respect to other subtypes of epithelial ovarian cancer (EOC). This study was undertaken to compare response and survival to platinum-based chemotherapy between patients with advanced stage III and IV OCCC and serous EOC (sEOC). PATIENTS AND METHODS: A retrospective analysis was performed in patients with advanced stage of OCCC treated with first-line platinum-based chemotherapy in the context of several study protocols of the Hellenic Cooperative Oncology Group (HeCOG) between 1/2/1987 and 31/10/2003. The outcome was compared to that of patients with sEOC treated according to the same protocols during the same study period. RESULTS: One hundred and five patients (35 stage III and IV OCCC, 70 stage III and IV sEOC) treated with platinum-based chemotherapy were analyzed. The overall response rate for OCCC was 45% (complete response 25%) (95% CI, 23.1% to 68.5%) and 81% (complete response 46%) (95% CI, 67.4% to 91.1%) for sEOC. The overall response rate was significantly higher for sEOC (P = 0.008). In the subgroup of stage III patients, the rate of complete responders was higher among sEOC patients (P = 0.023). After a median follow-up of 61.1 months, median survival and time to tumor progression were not significantly different between the two groups (25.1 months [95% CI 11.7 to 38.5 months] versus 49.1 months [95% CI 36.5 to 61.6 months], P = 0.141, 12.0 months [95% CI 6.5 to 17.3 months] versus 18.0 months [95% CI 14.7 to 21.6 months], P = 0.384, respectively). CONCLUSION: Patients with OCCC have significantly lower response to platinum-based first-line chemotherapy compared to patients with sEOC. This low response to platinum-based chemotherapy was not translated in significantly shorter survival. The current study outcomes are provocative and suggest that a new strategy for chemotherapy in OCCC should be adopted, possibly one that focuses on new agents without cross-resistance to platinum agents.
Περιγραφή
Λέξεις-κλειδιά
Adenocarcinoma, Clear Cell/*drug therapy/pathology/surgery, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Carboplatin/administration & dosage, Cisplatin/administration & dosage, Combined Modality Therapy, Cyclophosphamide/administration & dosage, Cystadenocarcinoma, Serous/*drug therapy/pathology/surgery, Doxorubicin/administration & dosage, Epirubicin/administration & dosage, Female, Humans, Middle Aged, Neoplasm Staging, Ovarian Neoplasms/*drug therapy/pathology/surgery, Paclitaxel/administration & dosage, Retrospective Studies, Survival Rate
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16516283
http://ac.els-cdn.com/S0090825805011200/1-s2.0-S0090825805011200-main.pdf?_tid=3e9848d38435cab6a547c7f07b2c76ae&acdnat=1333613418_e738b98042bfb37ba643cbe05ac9a8de
http://ac.els-cdn.com/S0090825805011200/1-s2.0-S0090825805011200-main.pdf?_tid=3e9848d38435cab6a547c7f07b2c76ae&acdnat=1333613418_e738b98042bfb37ba643cbe05ac9a8de
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής