Voxel-based diffusion tensor imaging detects pyramidal tract degeneration in primary lateral sclerosis
| dc.contributor.author | Tzarouchi, L. C. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Giannopoulos, S. | en |
| dc.contributor.author | Astrakas, L. G. | en |
| dc.contributor.author | Diakou, M. | en |
| dc.contributor.author | Argyropoulou, M. I. | en |
| dc.date.accessioned | 2015-11-24T19:36:13Z | |
| dc.date.available | 2015-11-24T19:36:13Z | |
| dc.identifier.issn | 1748-880X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23831 | |
| dc.rights | Default Licence | - |
| dc.subject | Case-Control Studies | en |
| dc.subject | Diffusion Magnetic Resonance Imaging | en |
| dc.subject | Disease Progression | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Middle Aged | en |
| dc.subject | Motor Neuron Disease/*pathology/physiopathology | en |
| dc.subject | Motor Neurons/physiology | en |
| dc.subject | Neural Conduction/physiology | en |
| dc.subject | Prognosis | en |
| dc.subject | Pyramidal Tracts/*pathology/physiopathology | en |
| dc.title | Voxel-based diffusion tensor imaging detects pyramidal tract degeneration in primary lateral sclerosis | en |
| heal.abstract | OBJECTIVE: Primary lateral sclerosis (PLS) is a progressive degenerative disorder affecting upper motor neurons and requires a clinical diagnosis. Diffusion tensor imaging (DTI) is a quantitative method for assessing white matter fibre integrity. The purpose of the study was to evaluate the involvement of upper motor neurons by using DTI in PLS. METHODS: A patient with PLS was compared with eight age-matched controls. Differences in fractional anisotropy (FA) index were assessed using DTI on a voxel-by-voxel basis. RESULTS: Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells. CONCLUSION: Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1259/bjr/14368804 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21172968 | - |
| heal.identifier.secondary | http://bjr.birjournals.org/content/84/997/78.full.pdf | - |
| heal.journalName | Br J Radiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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