Fruit and vegetable intake and the risk of gastric adenocarcinoma: a re-analysis of the European prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up

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dc.contributor.authorGonzalez, C. A.en
dc.contributor.authorLujan-Barroso, L.en
dc.contributor.authorde Mesquita, H. B.en
dc.contributor.authorJenab, M.en
dc.contributor.authorDuell, E. J.en
dc.contributor.authorAgudo, A.en
dc.contributor.authorTjonneland, A.en
dc.contributor.authorBoutron-Ruault, M. C.en
dc.contributor.authorClavel-Chapelon, F.en
dc.contributor.authorTouillaud, M.en
dc.contributor.authorTeucher, B.en
dc.contributor.authorKaaks, R.en
dc.contributor.authorBoeing, H.en
dc.contributor.authorSteffen, A.en
dc.contributor.authorTrichopoulou, A.en
dc.contributor.authorRoukos, D.en
dc.contributor.authorKarapetyan, T.en
dc.contributor.authorPalli, D.en
dc.contributor.authorTagliabue, G.en
dc.contributor.authorMattiello, A.en
dc.contributor.authorTumino, R.en
dc.contributor.authorRicceri, F.en
dc.contributor.authorSiersema, P. D.en
dc.contributor.authorNumans, M. E.en
dc.contributor.authorPeeters, P. P.en
dc.contributor.authorParr, C. L.en
dc.contributor.authorSkeie, G.en
dc.contributor.authorLund, E.en
dc.contributor.authorRamon Quiros, J.en
dc.contributor.authorSanchez-Cantalejo, E.en
dc.contributor.authorNavarro, C.en
dc.contributor.authorBarricarte, A.en
dc.contributor.authorDorronsoro, M.en
dc.contributor.authorEhrnstrom, R.en
dc.contributor.authorRegner, S.en
dc.contributor.authorKhaw, K. T.en
dc.contributor.authorWareham, N.en
dc.contributor.authorKey, T. J.en
dc.contributor.authorCrowe, F. L.en
dc.contributor.authorBlaker, H.en
dc.contributor.authorRomieu, I.en
dc.contributor.authorRiboli, E.en
dc.date.accessioned2015-11-24T19:15:17Z
dc.date.available2015-11-24T19:15:17Z
dc.identifier.issn1097-0215-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21488
dc.rightsDefault Licence-
dc.titleFruit and vegetable intake and the risk of gastric adenocarcinoma: a re-analysis of the European prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-upen
heal.abstractIn a previous EPIC analysis we found an inverse association between total intake of vegetables and onion and garlic and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to re-analyse the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a sub-sample was used to correct for dietary measurement errors. Comparing the highest vs lowest quintile of intake, we found an inverse association between total intake of V&F and GC risk (HR 0.77; 95% CI 0.57-1.04; p for trend 0.02), between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.36-0.97; p for trend 0.03), and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.38-1.00, p for trend 0.01). Although calibration revealed somewhat stronger inverse associations none of the risks reached statistical significance. There was no association between total or specific vegetables intake and GC risk. The inverse association between fresh fruit and citrus fruits and risk of GC seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC respectively. (c) 2012 Wiley-Liss, Inc.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/ijc.27565-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22473701-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/doi/10.1002/ijc.27565/abstract-
heal.journalNameInt J Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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