Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation
| dc.contributor.author | Kounis, N. G. | en |
| dc.contributor.author | Frangides, C. | en |
| dc.contributor.author | Papadaki, P. J. | en |
| dc.contributor.author | Zavras, G. M. | en |
| dc.contributor.author | Goudevenos, J. | en |
| dc.date.accessioned | 2015-11-24T19:23:40Z | |
| dc.date.available | 2015-11-24T19:23:40Z | |
| dc.identifier.issn | 0160-9289 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22352 | |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Amiodarone/*adverse effects/therapeutic use | en |
| dc.subject | Anti-Arrhythmia Agents/*adverse effects/therapeutic use | en |
| dc.subject | Atrial Flutter/drug therapy | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Skin Diseases/*chemically induced | en |
| dc.subject | Skin Pigmentation/*drug effects | en |
| dc.title | Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation | en |
| heal.abstract | A 66-year-old man suffering from atrial flutter developed cutaneous blue-gray pigmentation while receiving 600 mg of amiodarone daily for 15 months. With reduction of the dose to 100 mg, skin discoloration disappeared within 16 months, to reappear within 7 months after increasing the dose to 400 mg. Finally, the discoloration disappeared within 13 months with a dose reduction to 200 mg daily. It seems that a tissue threshold level for amiodarone exists in this patient, above which skin discoloration appears and below which it fades. Dose, duration, metabolism, macrophage transfer, and spillover saturation-excretion may be relevant in amiodarone-induced skin pigmentation. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8818442 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/clc.4960190713/asset/4960190713_ftp.pdf?v=1&t=h0lzn5wu&s=5ba0a6bba1a25678c58fa1af206f64bb5e8e1b86 | - |
| heal.journalName | Clin Cardiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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